N(8)-acetylspermidine

Three steps

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SAT1, SAT2, HADHA, ACADVL and 1 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SAT1, SAT2, HADHA, ACADVL and 1 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SAT1, SAT2, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SAT1, SAT2, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SAT1, SAT2, ACSM4, ACSM1 and 4 morecytosolOne of 6 routes

• 17alpha,21-dihydroxypregnenoloneReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450

  Catalysed by HDAC10, CYP17A1, CYP21A2endoplasmic reticulum, cytosol

• elaidic acidReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• 11-deoxycortisolReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by HDAC10, CYP17A1, CYP21A2endoplasmic reticulum, cytosolOne of 3 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by HDAC10, ASAH1, PLA2G15One of 3 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by HDAC10, CYP17A1endoplasmic reticulum, cytosolOne of 6 routes

• CHEBI:28701Reach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SAT1, SAT2, ACAA1, SCP2 and 1 morecytosol, peroxisomeOne of 7 routes

• chlorine(.)Reach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and formate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A1 and 1 moreextracellular space, cytosolOne of 2 routes

• 3-acetamidopropanalReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming)

  Catalysed by SAT1, SAT2, PAOX, SMOXcytosolOne of 4 routes

• 3-hydroxypyruvic acidReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

• 3-oxopropanoateReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• a phenolReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. a phenyl acetate + H2O = a phenol + acetate + H(+)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by HDAC10, PON1, PON2, PON3

• D-serineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. D-serine = pyruvate + NH4(+)

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• (R)-lactic acidReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A6 and 4 moreextracellular space, cytosol

• 2-iminopropanoateReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• phosphoenolpyruvic acidReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 4 moreextracellular space, cytosol

• 13-cis-retinalReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A7 and 2 moreextracellular space, cytosol, endoplasmic reticulum

• N-acetyl-beta-neuraminic acidReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• L-ornithineReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  3. L-ornithine + H(+) = putrescine + CO2

  Catalysed by SRM, ODC1cytosolOne of 2 routes

• taurineReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SAT1, SAT2, BAATcytosolOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• acetoacetyl-CoAReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A6 and 3 moreextracellular space, cytosolOne of 2 routes

• glycineReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by SAT1, SAT2, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SAT1, SAT2, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SAT1, SAT2cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SAT1, SAT2, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SAT1, SAT2cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SAT1, SAT2, ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SAT1, SAT2, ACSM4, ACSM1 and 4 morecytosolOne of 11 routes

• dodecanoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. Production of Glutaryl Carnitine

  Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SAT1, SAT2, SUCLG1, SUCLG2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by SAT1, SAT2, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. phytanate-CoA ligase

  Catalysed by SAT1, SAT2cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 5 morecytosolOne of 15 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• sphing-4-enineReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SAT1, SAT2, ASAH1, ACER2 and 2 morecytosol, Golgi apparatusOne of 3 routes

• N-acetyl-alpha-D-glucosamine 1-phosphateReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate
  3. N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate

  Catalysed by HDAC10, AMDHD2, PGM3

• L-methionineReach from here →
  1. N8-acetylspermidine to spermidine conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by SAT1, SAT2, NAGScytosol, mitochondrial matrixOne of 2 routes

• a 2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. N(8)-acetylspermidine + H2O = spermidine + acetate
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine

  Catalysed by HDAC10, ASAH1, PLA2G15