L-alanine

Two steps

• 3,3'-diiodothyronamineReach from here →
  1. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  2. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by MOCOS, DIO1, DIO2One of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  2. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by MOCOS, DIO3

• 3,3',5'-triiodothyronamineReach from here →
  1. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  2. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by MOCOS, DIO3

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by HADHA, ACADVL, HADHBmitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by HADHA, ACADVL, HADHBmitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ECHS1, ACAA2, HADHmitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ECHS1, ACAA2, HADHmitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by AGXT, AGXT2, GLYAT, GLYATL2 and 1 moremitochondrial matrixOne of 3 routes

• a quinolReach from here →
  1. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)
  2. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by SLC1A4, PRODH2inner side of the membrane, outer side of the membraneOne of 2 routes

• hypochlorous acidReach from here →
  1. transport of alanine and chloride (cytosol to extracellular)
  2. Peroxidase

  Catalysed by SLC6A14, LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. transport of alanine and chloride (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)

  Catalysed by SLC6A14, SLC12A2, SLC12A1extracellular space, cytosolOne of 3 routes

• phenylacetylglycineReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by AGXT, AGXT2, GLYATmitochondrial matrix, cytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 2 moremitochondrial matrix, cytosolOne of 6 routes

• CHEBI:27760Reach from here →
  1. L-selenocysteine selenide-lyase (L-alanine-forming)
  2. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by SCLY, CTHcytosol

• elaidic acidReach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moremitochondrial matrix, cytosolOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC7A5, TPH1, TPH2extracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. LTD4 hydrolysis

  Catalysed by AGXT, AGXT2mitochondrial matrix, cytosol

• CHEBI:28701Reach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ACAA1, SCP2, MYO5Bmitochondrial matrix, peroxisomeOne of 7 routes

• 3-disulfanyl-L-alanineReach from here →
  1. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter
  2. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC7A9, SLC3A1, CTHextracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. transport of alanine and cysteine (cytosol to extracellular)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC7A5, NAGSextracellular space, cytosol, mitochondrial matrix

• K(+)Reach from here →
  1. transport of alanine and cysteine (cytosol to extracellular)
  2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC7A5, SLC1A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Cys-tRNA(Cys)Reach from here →
  1. transport of alanine and cysteine (cytosol to extracellular)
  2. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC7A5, CARS1extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. transport of alanine and phenylalanine (cytosol to extracellular)
  2. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC7A5, FARSB, FARSAextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by AGXT, AGXT2, GARS1mitochondrial matrix, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by AGXT2, DARS1cytosol

• Trp-tRNA(Trp)Reach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC7A5, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. transport of alanine and isoleucine (cytosol to extracellular)
  2. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC7A5, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. transport of alanine and glutamine (cytosol to extracellular)
  2. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, QARS1extracellular space, cytosol

• isocyanateReach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by SLC7A6, LACC1extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. transport of alanine and asparagine (cytosol to extracellular)
  2. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC7A5, NARS1extracellular space, cytosol

• hydrogenselenideReach from here →
  1. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by MOCOS, SCLY

• glycocholateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by AGXT, AGXT2, BAATmitochondrial matrix, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. transport of alanine and cysteine (cytosol to extracellular)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLC7A5, CTHextracellular space, cytosolOne of 2 routes

• acetateReach from here →
  1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC7A5, IDO1, TDO2, IDO2extracellular space, cytosol

• formic acidReach from here →
  1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  2. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A7 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

• anthranilic acidReach from here →
  1. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  2. L-Kynurenine hydrolase

  Catalysed by KYNUcytosol

• propionic acidReach from here →
  1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  2. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• butyric acidReach from here →
  1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  2. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• malonic acidReach from here →
  1. transport of alanine and chloride (cytosol to extracellular)
  2. Malonate Transport, Antiport with Chloride

  Catalysed by SLC6A14extracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  2. L-Serine:pyruvate aminotransferase

  Catalysed by AGXT2, AGXTmitochondrial matrix, cytosolOne of 2 routes

• L-lysineReach from here →
  1. transport of alanine and leucine (cytosol to extracellular)
  2. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by SLC7A5, SLC7A7extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• D-lysineReach from here →
  1. transport of alanine and ornithine (cytosol to extracellular)
  2. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by SLC7A6, SLC3A2, SLC7A7extracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. transport of alanine and ornithine (cytosol to extracellular)
  2. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-carbamoyl-L-aspartateReach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by AGXT2, CAD

• 3-oxopropanoateReach from here →
  1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by AGXT2mitochondrial matrixOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. transport of alanine and methionine (cytosol to extracellular)
  2. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A5, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. transport of alanine and cysteine (cytosol to extracellular)
  2. De novo synthesis of 2Fe2S

  Catalysed by SLC7A5, NDUFAB1, FDXR, FXN and 4 moreextracellular space, cytosol, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. transport of alanine and isoleucine (cytosol to extracellular)
  2. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC7A5, BCAT2, BCAT1extracellular space, cytosol