choloyl-CoA

Three steps

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, GPX4inner side of the membrane, outer side of the membrane

• deoxycholate 3-sulfateReach from here →
  1. choloyl-CoA + H2O = cholate + CoA + H(+)
  2. cytochrome P450 (cholate)
  3. deoxycholate + 3'-phosphoadenylyl sulfate = deoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ACOT8, BAAT, CYP7A1, SULT2A1cytosol

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by BAAT, ABCC4, GSTP1inner side of the membrane, outer side of the membrane

• a quinolReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by BAAT, ABCC4, SQORinner side of the membrane, outer side of the membrane

• 5(S)-HETEReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by BAAT, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and LTD4 (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• L-ascorbic acidReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by BAAT, ABCC4, CLIC1, GSTO1 and 1 moreinner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by BAAT, ABCC4, TSTD1inner side of the membrane, outer side of the membrane

• adipic acidReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by BAAT, SLC22A24, SUGCTinner side of the membrane, outer side of the membrane

• an alcoholReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, CP, PRDX6inner side of the membrane, outer side of the membrane

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• serotoninReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• chenodeoxycholateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• glycochenodeoxycholateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by BAAT, ABCC4inner side of the membrane, outer side of the membrane

• glycolithocholic acidReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• tert-butanolReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, CLIC2, GPX1 and 3 moreinner side of the membrane, outer side of the membrane

• gamma-Glu-AlaReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, GGT1 and 5 moreextracellular space, cytosol

• 3,3',5-triiodo-L-thyronineReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glutaryl-CoAReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  3. glutarate + succinyl-CoA = glutaryl-CoA + succinate

  Catalysed by BAAT, SLC22A24, SUGCTinner side of the membrane, outer side of the membraneOne of 4 routes

• prostaglandin E1Reach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin I2Reach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 6 routes

• prostaglandin H2Reach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin D2Reach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by BAAT, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosolOne of 2 routes

• leukotriene A4Reach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• (R)-S-lactoylglutathioneReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, GLO1 and 1 moreextracellular space, cytosolOne of 3 routes

• S-formylglutathioneReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, ADH1C and 5 moreextracellular space, cytosolOne of 2 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• leukotriene C4Reach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. leukotriene C4 synthase (GSH)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, LTC4Sextracellular space, cytosolOne of 7 routes

• glutathione disulfideReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by BAAT, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosolOne of 35 routes

• taurolithocholate 3-sulfateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• 5-oxo-L-prolineReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by BAAT, ABCC4, CHAC2, CHAC1inner side of the membrane, outer side of the membrane

• histamineReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-thyroxineReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• kynurenateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by BAAT, SLC22A24, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• deoxycholoyl-CoAReach from here →
  1. choloyl-CoA + H2O = cholate + CoA + H(+)
  2. cytochrome P450 (cholate)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ACOT8, BAAT, CYP7A1, SLC27A2 and 1 morecytosolOne of 3 routes

• S-sulfanylglutathioneReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by BAAT, SLCO1A2, SLCO1B3, SQORextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• dopamineReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycolithocholate 3-sulfateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• estrone 3-sulfateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin E2Reach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 6 routes

• L-cysteinylglycineReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by BAAT, SLCO1A2, SLCO1B3, GGTLC3 and 5 moreextracellular space, cytosolOne of 6 routes

• ubiquinol-10Reach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by BAAT, ABCC4, SQORinner side of the membrane, outer side of the membrane

• (R)-noradrenalineReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by BAAT, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• ursodeoxycholateReach from here →
  1. choloyl-CoA + glycine = glycocholate + CoA + H(+)
  2. solute carrier organic anion transporter (glycocholate)
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes