3-(4-hydroxyphenyl)pyruvate

Three steps

• L-isoleucineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. transport of isoleucine and phenylalanine (cytosol to extracellular)

  Catalysed by TAT, PAH, SLC7A5extracellular space, cytosolOne of 9 routes

• CHEBI:17203Reach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. transport of phenylalanine and proline (cytosol to extracellular)

  Catalysed by TAT, PAH, SLC7A5extracellular space, cytosolOne of 6 routes

• aceneuramateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by AADAT, AGXT, AGXT2, NPL

• 5'-deoxyadenosineReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by AADAT, AGXT, AGXT2, TYW1B and 1 more

• sulfiteReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by AADAT, CLYBL, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:17380Reach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
  3. Kynurenine-Oxoglutarate Transaminase

  Catalysed by AADAT, KYAT3mitochondrial matrixOne of 2 routes

• enol-oxaloacetateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by AADAT, CLYBL, SDHB, SDHA

• 5-aminolevulinic acidReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by TAT, AADAT, ALAS1, ALAS2 and 1 moremitochondrial matrix

• L-cysteineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by TAT, PAH, SLC7A5extracellular space, cytosolOne of 10 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by TAT, PAH, TPH1, TPH2

• CHEBI:17895Reach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. transport of phenylalanine and tyrosine (cytosol to extracellular)

  Catalysed by TAT, PAH, SLC7A5extracellular space, cytosolOne of 9 routes

• fumaric acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. (S)-malate hydro-lyase (fumarate-forming)

  Catalysed by AADAT, CLYBL, FHcytosolOne of 5 routes

• CHEBI:18019Reach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. transport of lysine and phenylalanine (cytosol to extracellular)

  Catalysed by TAT, PAH, SLC7A6extracellular space, cytosolOne of 4 routes

• 4-fumarylacetoacetateReach from here →
  1. 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)
  2. Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
  3. 4-Maleylacetoacetate cis-trans-isomerase

  Catalysed by HPD, HGD, GSTZ1cytosolOne of 2 routes

• L-glutamineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. transport of glutamine and phenylalanine (cytosol to extracellular)

  Catalysed by TAT, PAH, SLC7A5extracellular space, cytosolOne of 13 routes

• dTDPReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. pyruvate kinase (dTDP)

  Catalysed by AADAT, AGXT, AGXT2, PKM and 1 morecytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by TAT, AADAT, GARTcytosol

• 2-phenylethylamineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by TAT, PAH, DDCcytosol

• ophthalmateReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by TAT, AADAT, GSS

• S-methylmercury-L-cysteineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)

  Catalysed by TAT, PAH, SLC7A8inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by AADAT, AGXT2, BCKDHA, BCKDHBmitochondrial matrix

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by TAT, AADAT, AGXT2One of 3 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by TAT, AADAT, SHMT1cytosolOne of 2 routes

• CHEBI:240943Reach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by TAT, AADAT, GLYAT, GLYATL2 and 1 moremitochondrial matrix

• a quinolReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by AADAT, CLYBL, SDHB, SDHA

• potassium atomReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. transport of aspartate (cytosol to extracellular)

  Catalysed by TAT, SLC7A13, SLC1A7, SLC1A3 and 3 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• phenylacetylglycineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by TAT, AADAT, GLYATcytosolOne of 3 routes

• selenomethionineReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by AADAT, AGXT2, CTHcytosol

• CHEBI:27760Reach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by AADAT, AGXT2, CTHcytosol

• (2-hydroxyphenyl)acetic acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by AADAT, HPDcytosol

• 2-oxopentanoateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by AADAT, AGXT2

• CHEBI:28666Reach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. LTD4 hydrolysis

  Catalysed by TAT, AADATcytosol

• a dicarboxylateReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by TAT, PAH, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 4 routes

• L-ascorbic acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate
  3. N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by AADAT, PAMOne of 6 routes

• K(+)Reach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by TAT, SLC7A13, SLC1A7, SLC1A3 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 3-methyl-1-hydroxybutylthiamine diphosphateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine
  3. branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)

  Catalysed by AADAT, BCKDHA, BCKDHBmitochondrial matrix

• Phe-tRNA(Phe)Reach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by TAT, PAH, FARSB, FARSAcytosol

• Gly-tRNA(Gly)Reach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by TAT, AADAT, GARS1cytosol

• Asp-tRNA(Asp)Reach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by TAT, SLC7A13, DARS1inner side of the membrane, outer side of the membrane, cytosol

• chlorine(.)Reach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by TAT, PAH, SLC6A14extracellular space, cytosolOne of 5 routes

• glycocholateReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by TAT, AADAT, BAATperoxisomeOne of 3 routes

• acetateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by AADAT, AGXT, AGXT2, SLC16A4 and 4 moreextracellular space, cytosolOne of 2 routes

• formic acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by AADAT, AGXT, AGXT2, SLC16A4 and 4 moreextracellular space, cytosolOne of 2 routes

• propionic acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by AADAT, AGXT, AGXT2, SLC16A4 and 5 moreextracellular space, cytosolOne of 2 routes

• citric acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. Citrate Transport, Mitochondrial

  Catalysed by AADAT, CLYBL, SLC25A1mitochondrial matrix, cytosolOne of 5 routes

• butyric acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by AADAT, AGXT, AGXT2, SLC16A4 and 5 moreextracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. L-Serine:pyruvate aminotransferase

  Catalysed by AADAT, AGXT, AGXT2cytosolOne of 2 routes

• isocitric acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by AADAT, CLYBL, SLC25A1mitochondrial matrix, cytosolOne of 3 routes

• glutarateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by AADAT, KYAT3, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• cis-aconitic acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by AADAT, CLYBL, SLC25A1mitochondrial matrix, cytosolOne of 3 routes