L-homocysteine thiolactone

Three steps

• L-cysteineReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. L-serine hydro-lyase (adding homocysteine
  3. L-cystathionine cysteine-lyase (deaminating

  Catalysed by PON1, PON2, PON3, CBS and 1 morecytosolOne of 10 routes

• CHEBI:17895Reach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. transport of methionine and tyrosine (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosol, extracellular spaceOne of 4 routes

• CHEBI:18019Reach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. transport of lysine and methionine (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosol, extracellular spaceOne of 2 routes

• L-glutamineReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. transport of glutamine and methionine (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosol, extracellular spaceOne of 6 routes

• S-methylmercury-L-cysteineReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by BPHL, CTH, BCKDHA, BCKDHBmitochondrial matrix

• (6R)-10-formyltetrahydrofolateReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine
  3. (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate

  Catalysed by BPHL, MTR, MTHFD1, MTHFD1L

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)
  3. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate

  Catalysed by BPHL, CTH, AGXT2

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosolOne of 5 routes

• a quinolReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by BPHL, CTH, SQOR

• selenomethionineReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by BPHL, CTHcytosol

• CHEBI:27760Reach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by BPHL, CTHcytosol

• 5(S)-HETEReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by PON1, PON2, PON3, GPX5 and 8 morecytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. transport of GSH and LTD4 (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• a thiolReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)
  3. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by BPHL, CTH, SUMF1

• chlorine(.)Reach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. transport of chloride and methionine (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosol, extracellular spaceOne of 2 routes

• glycocholateReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by PON1, PON2, PON3, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• cholateReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. solute carrier organic anion transporter (cholate)

  Catalysed by PON1, PON2, PON3, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• L-aspartateReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3cytosol, extracellular spaceOne of 2 routes

• thiosulfateReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by BPHL, CTH, TSTD1One of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosol

• serotoninReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• L-alpha-aminobutyric acidReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)
  3. glutamic-pyruvic transaminase ((S)-2-aminobutanoate)

  Catalysed by BPHL, CTH, GPTcytosol

• taurocholateReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. solute carrier organic anion transporter (GSH)

  Catalysed by PON1, PON2, PON3, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• glyoxylateReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by BPHL, CTH, AGXT2

• glycolithocholic acidReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• L-ornithineReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. transport of methionine and ornithine (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosol, extracellular spaceOne of 2 routes

• gamma-Glu-AlaReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. gamma-glutamyltransferase (alanine)

  Catalysed by PON1, PON2, PON3, GGT1 and 5 morecytosol, extracellular space

• 3,3',5-triiodo-L-thyronineReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• glycineReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. transport of glycine and methionine (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosol, extracellular spaceOne of 9 routes

• prostaglandin E1Reach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• prostaglandin I2Reach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• prostaglandin H2Reach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• prostaglandin D2Reach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by PON1, PON2, PON3, GPX5 and 8 morecytosol

• sarcosineReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine
  3. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]

  Catalysed by BPHL, BHMT, DMGDH

• 7,8-dihydrofolateReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase

  Catalysed by PON1, PON2, PON3, MTR and 2 morecytosolOne of 3 routes

• 5-formimidoyltetrahydrofolateReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosolOne of 2 routes

• leukotriene A4Reach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• (R)-S-lactoylglutathioneReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by PON1, PON2, PON3, GLO1 and 1 morecytosolOne of 2 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by BPHL, CTH, MPST

• S-formylglutathioneReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by PON1, PON2, PON3, ADH1C and 5 morecytosol

• L-tryptophanReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. transport of methionine and tryptophan (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosol, extracellular spaceOne of 4 routes

• glutathioneReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by BPHL, CTH, TSTD1

• L-threonineReach from here →
  1. L-homocysteine thiolactone + H2O = L-homocysteine + H(+)
  2. L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)
  3. L-threonine = 2-oxobutanoate + NH4(+)

  Catalysed by BPHL, CTH, SDS, SDSL

• L-alanineReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. transport of alanine and methionine (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosol, extracellular spaceOne of 7 routes

• leukotriene C4Reach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. Formation of Homocystine
  3. leukotriene C4 synthase (GSH)

  Catalysed by PON1, PON2, PON3, LTC4ScytosolOne of 4 routes

• L-asparagineReach from here →
  1. arylesterase (homocysteine-thiolactone)
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. transport of asparagine and methionine (cytosol to extracellular)

  Catalysed by PON1, PON2, PON3, MTR and 1 morecytosol, extracellular spaceOne of 3 routes