(6R)-5,10-methylenetetrahydrofolic acid

Three steps

• L-arginineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A6cytosol, extracellular spaceOne of 7 routes

• CHEBI:16523Reach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SHMT1, SLC3A2, SLC7A10cytosol, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. PROTEIN_BS

  Catalysed by SHMT1cytosolOne of 2 routes

• Met-tRNA(Met)Reach from here →
  1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by MTHFR, MTR, MARS1cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by MTHFR, MTR, AADATcytosol

• 2-oxobutanoateReach from here →
  1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  2. Methionine Synthase
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by MTHFR, CTHcytosol, nucleus

• CHEBI:16856Reach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by SHMT1, GSScytosol

• CHEBI:16857Reach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by SHMT1, SLC3A2, SLC7A5, SLC7A10cytosol, extracellular spaceOne of 7 routes

• glyoxylic acidReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SHMT1, DAOcytosol, peroxisome

• L-isoleucineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5cytosol, extracellular spaceOne of 7 routes

• CHEBI:17203Reach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5, SLC7A6cytosol, extracellular spaceOne of 5 routes

• AH2Reach from here →
  1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by MTHFR, MTR, CDKAL1cytosolOne of 3 routes

• 5-aminolevulinic acidReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SHMT1, ALAS1, ALAS2, CPNE7cytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by SHMT1, SLC3A2, SLC7A5, SLC7A8cytosol, extracellular spaceOne of 10 routes

• CHEBI:17895Reach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5cytosol, extracellular spaceOne of 9 routes

• CHEBI:18019Reach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A6cytosol, extracellular spaceOne of 4 routes

• triphosphateReach from here →
  1. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  2. dTTP + H2O = dTMP + diphosphate + H(+)
  3. dTTP + H2O = thymidine + triphosphate + H(+)

  Catalysed by TYMS, ASMTL, SAMHD1cytosol

• L-glutamineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5cytosol, extracellular spaceOne of 10 routes

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by SHMT1, MTHFD1, GARTcytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SHMT1, GARTcytosol

• CHEBI:18381Reach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by SHMT1, MTHFD1, ATICcytosolOne of 2 routes

• (6S)-5-methyl-5,6,7,8-tetrahydrofolateReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in)

  Catalysed by SHMT1, ATIC, SLC19A1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• ophthalmateReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SHMT1, GSScytosol

• S-methylmercury-L-cysteineReach from here →
  1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by MTHFR, MTR, SLC7A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SHMT1, AGXT2cytosol

• CHEBI:240943Reach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SHMT1, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrix

• phenylacetylglycineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SHMT1, GLYATcytosolOne of 3 routes

• 5-hydroxytryptophanReach from here →
  1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  2. 5-methyl-THF to 5,10-methylene-THF conversion
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by MTHFR, TPH1, TPH2cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. LTD4 hydrolysis

  Catalysed by SHMT1cytosol

• Gly-tRNA(Gly)Reach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SHMT1, GARS1cytosol

• chlorine(.)Reach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by SHMT1, SLC6A9, SLC6A14cytosol, extracellular spaceOne of 5 routes

• glycocholateReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SHMT1, BAATcytosol, peroxisomeOne of 3 routes

• L-aspartateReach from here →
  1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)

  Catalysed by MTHFR, MTR, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. 5-methyltetrahydrofolate:NADP+ oxidoreductase
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by MTHFR, MTR, IL4I1cytosol

• 5-aminolevulinateReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SHMT1, ALAS1, ALAS2cytosol

• glycochenodeoxycholateReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SHMT1, BAATcytosol

• glycochenodeoxycholic acidReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SHMT1, BAATcytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SHMT1, AADATcytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by SHMT1, BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SHMT1, GCATcytosol, mitochondrial matrix

• phosphoenolpyruvic acidReach from here →
  1. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  2. dTTP + H2O = dTMP + diphosphate + H(+)
  3. pyruvate kinase (dTDP)

  Catalysed by TYMS, ASMTL, PKM, PKLRcytosol

• L-ornithineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-Arginine:glycine amidinotransferase

  Catalysed by SHMT1, GATMcytosolOne of 7 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SHMT1, GLDC, GCSHcytosol, mitochondrial matrix

• 2-deoxy-alpha-D-ribose 1-phosphateReach from here →
  1. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  2. thymidylate 5'-phosphohydrolase
  3. thymidine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + thymine

  Catalysed by TYMS, ACP3, NT5E, NT5C2 and 8 morecytosol

• sarcosineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by SHMT1, PIPOXcytosolOne of 2 routes

• dCMPReach from here →
  1. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  2. deoxythymidylate kinase (dADP)
  3. cytidine/uridine monophosphate kinase (dADP)

  Catalysed by TYMS, DTYMK, CMPK1cytosol, mitochondrial matrixOne of 2 routes

• an N-acylglycineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by SHMT1, GLYATL3, GLYAT, GLYATL2cytosol

• dGMPReach from here →
  1. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  2. deoxythymidylate kinase (dADP)
  3. dADP to dATP conversion

  Catalysed by TYMS, DTYMKcytosol, mitochondrial matrix

• guanidinoacetateReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-Arginine:glycine amidinotransferase

  Catalysed by SHMT1, GATMcytosolOne of 2 routes

• L-tryptophanReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5cytosol, extracellular spaceOne of 9 routes