cholesteryl 3-beta-D-glucoside

Three steps

• a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by GBA1, GBA2, UGT8One of 3 routes

• D-gluconateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. D-glucose + NAD(+) = D-glucono-1,5-lactone + NADH + H(+)
  3. D-glucono-1,5-lactone + H2O = D-gluconate + H(+)

  Catalysed by GBA1, GBA2, H6PD, RGN

• a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

  Catalysed by GBA1, GBA2, GBA3One of 3 routes

• beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = N-(9Z-octadecenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
  3. N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + UDP + H(+)

  Catalysed by GBA1, GBA2, UGCG

• 1D-myo-inositol 1,4,5-trisphosphateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(in) + cholesterol(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

  Catalysed by GBA1, GBA2, OSBP2, OSBPL2 and 13 moreinner side of the membrane, outer side of the membrane

• NAADPHReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
  3. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)

  Catalysed by GBA1, GBA2, ADPGK, G6PD

• octadecanoateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. octadecanoyl-CoA + cholesterol = cholesteryl octadecanoate + CoA
  3. Steryl-ester acylhydrolase

  Catalysed by GBA1, GBA2, SOAT1, CEL and 1 morelysosomeOne of 3 routes

• octanoateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside
  3. N-octanoylsphing-4-enine + H2O = octanoate + sphing-4-enine

  Catalysed by GBA1, GBA2, ASAH1, ASAH2

• beta-D-galactoseReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+)
  3. lactose + H2O = beta-D-galactose + D-glucose

  Catalysed by GBA1, GBA2, B4GALT2, B4GALT1 and 1 more

• a ganglioside GA2 (d18:1(4E))Reach from here →
  1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
  3. beta-1,4-N-acetyl-galactosaminyltransferase (LacCer pool)

  Catalysed by GBA1, GBA2, B4GALT5, B4GALT6 and 1 morecytosolOne of 3 routes

• elaidic acidReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = N-(9Z-octadecenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
  3. H2O[g] + N-(9Z-octadecenoyl)-sphing-4-enine[g] = elaidate[g] + sphingosine[g]

  Catalysed by GBA1, GBA2, ACER3Golgi apparatus

• alpha-D-galactoseReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. UDP-alpha-D-galactose:D-glucose 4-beta-D-galactosyltransferase
  3. Lactose galactohydrolase

  Catalysed by GBA1, GBA2, B4GALT2, LALBA and 5 moreGolgi apparatus, extracellular spaceOne of 3 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by GBA1, GBA2, LCAT, TAFAZZIN

• beta-D-fructoseReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. Aldehyde Reductase
  3. D-Glucitol:NAD+ 2-oxidoreductase

  Catalysed by GBA1, GBA2, SORDcytosol

• 17alpha-hydroxypregnenoloneReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O
  3. cytochrome P450 (pregnenolone)

  Catalysed by GBA1, GBA2, CYP11A1, CYP17A1cytosolOne of 3 routes

• phosphocholineReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)

  Catalysed by GBA1, GBA2, LCAT, SMPD2 and 3 more

• (9Z)-octadecenoateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  3. Steryl-ester acylhydrolase

  Catalysed by GBA1, GBA2, SOAT2, SOAT1 and 2 morelysosomeOne of 5 routes

• a 1-O-alkyl-sn-glycero-3-phosphocholineReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-sn-glycero-3-phosphocholine

  Catalysed by GBA1, GBA2, LCAT

• (15Z)-tetracosenoateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
  3. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine

  Catalysed by GBA1, GBA2, ACER2, ACER1 and 1 more

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
  3. sterol esterase (Cholesteryl Arachidonate)

  Catalysed by GBA1, GBA2, SOAT2, SOAT1 and 2 morelysosome

• fatty acidReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. N-Acylsphingosine amidohydrolase

  Catalysed by GBA1, GBA2, ASAH1lysosome

• a fatty aldehydeReach from here →
  1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
  3. a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)

  Catalysed by GBA1, GBA2, ASAH1, ALDH3A2

• 7alpha,25-dihydroxycholesterolReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. cytochrome P450 (25-hydroxycholesterol)

  Catalysed by GBA1, GBA2, CH25H, CYP7B1endoplasmic reticulumOne of 2 routes

• (24S)-7alpha-dihydroxycholesterolReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
  3. 7alpha-hydroxycholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-7alpha-dihydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by GBA1, GBA2, CYP7A1, CYP46A1One of 4 routes

• keto-D-fructoseReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. Aldehyde Reductase
  3. keto-D-fructose + NADH + H(+) = D-sorbitol + NAD(+)

  Catalysed by GBA1, GBA2, SORDcytosol

• an isogloboside iGb3Cer (d18:1(4E))Reach from here →
  1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
  3. a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = an isogloboside iGb3Cer (d18:1(4E)) + UDP + H(+)

  Catalysed by GBA1, GBA2, B4GALT5, B4GALT6 and 1 more

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)

  Catalysed by GBA1, GBA2, OSBP, OSBPL9 and 5 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by GBA1, GBA2, CH25H, MTO1

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)

  Catalysed by GBA1, GBA2, LCAT, ENPP2 and 2 more

• dCMPReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. dATP:D-glucose 6-phosphotransferase
  3. cytidine/uridine monophosphate kinase (dADP)

  Catalysed by GBA1, GBA2, HK1, HK2 and 3 morecytosolOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)

  Catalysed by GBA1, GBA2, OSBP, OSBPL3inner side of the membrane, outer side of the membraneOne of 2 routes

• dGMPReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. dATP:D-glucose 6-phosphotransferase
  3. dADP to dATP conversion

  Catalysed by GBA1, GBA2, HK1, HK2 and 2 morecytosol, mitochondrial matrix

• an N-acylsphing-4-enine 1-phosphateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)

  Catalysed by GBA1, GBA2, AGK, CERK

• sphing-4-enineReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by GBA1, GBA2, ASAH1, ACER2 and 2 moreGolgi apparatusOne of 15 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)Reach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(in) + cholesterol(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate

  Catalysed by GBA1, GBA2, OSBP2, OSBPL2 and 2 moreinner side of the membrane, outer side of the membrane

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate

  Catalysed by GBA1, GBA2, OSBP, SYNJ2 and 3 moreinner side of the membrane, outer side of the membrane

• 6-phospho-D-glucono-1,5-lactoneReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. ATP:D-glucose 6-phosphotransferase
  3. D-glucose-6-phosphate:NADP+ 1-oxidoreductase

  Catalysed by GBA1, GBA2, HK1, GCK and 4 morecytosol, endoplasmic reticulumOne of 6 routes

• an acyl-CoAReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by GBA1, GBA2, ASAH1, ACER2 and 2 moreGolgi apparatusOne of 2 routes

• 1D-myo-inositol 3-phosphateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. ATP:D-glucose 6-phosphotransferase
  3. 1D-myo-inositol-3-phosphate lyase (isomerizing)

  Catalysed by GBA1, GBA2, HK1, GCK and 4 morecytosolOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA
  3. Steryl-ester acylhydrolase

  Catalysed by GBA1, GBA2, SOAT2, CEL and 1 morelysosomeOne of 3 routes

• D-mannose 6-phosphateReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
  3. D-glucose 6-phosphate = D-mannose 6-phosphate

  Catalysed by GBA1, GBA2, ADPGK, GPI

• a 2,3-dehydroacyl-CoAReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by GBA1, GBA2, CH25H, ACAD10

• a ganglioside GM3 (d18:1(4E))Reach from here →
  1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
  3. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)

  Catalysed by GBA1, GBA2, B4GALT5, B4GALT6 and 1 morecytosolOne of 3 routes

• Fe(II)-heme aReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2

  Catalysed by GBA1, GBA2, CH25H, COX15

• an all-trans-retinyl esterReach from here →
  1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid
  3. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)

  Catalysed by GBA1, GBA2, ASAH1, RPE65

• dTMPReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. dATP:D-glucose 6-phosphotransferase
  3. deoxythymidylate kinase (dADP)

  Catalysed by GBA1, GBA2, HK1, HK2 and 3 morecytosol, mitochondrial matrixOne of 2 routes

• pregn-5-ene-3,20-dioneReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O
  3. Pregnenolone:NAD+ 3-oxidoreductase

  Catalysed by GBA1, GBA2, CYP11A1, HSD3B1 and 1 morecytosolOne of 2 routes

• 4-methylpentan-1-olReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O
  3. aldose reductase (isocaproic-aldehyde)

  Catalysed by GBA1, GBA2, CYP11A1, AKR1B10 and 1 morecytosolOne of 2 routes

• a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine

  Catalysed by GBA1, GBA2, LCAT, ASPG

• Mo-molybdopterinReach from here →
  1. cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose
  2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by GBA1, GBA2, CH25H, MOCOS