Loading the page.
Proteins/UNIPROT:O60906
Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo. Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine..
Function from UniProtKB (O60906), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
31 statements
31 statements · 6 reference databases · Subject: SMPD2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
9 reactions
water+a sphingomyelinan N-acylsphing-4-enine+proton+CHEBI:18132
Catalysed by SMPD3 or SMPD2 or SMPD4 or SMPD1 or ENPP7
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.12cytosol
Human-GEM MAR00795CC BY 4.0Reference data
6 names
Resolves to: SMPD2
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.12lysosome
Human-GEM MAR00797CC BY 4.0Reference data
water+MAM02931cproton+CHEBI:18132+sphing-4-enine
Catalysed by SMPD3 or SMPD2 or SMPD4 or SMPD1 or ENPP7
Reaction pageLeft to rightBalancedEC 3.1.4.12cytosol
Human-GEM MAR08246CC BY 4.0Reference data
a sphingomyelin+waterphosphocholine+an N-acylsphing-4-enine+hydron
Catalysed by SMPD2 or SMPD1 or ENPP7 or SMPD4 or SMPD3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19253CC BY 4.0Reference data
1-O-hexadecyl-sn-glycero-3-phosphocholine+water1-O-hexadecyl-sn-glycerol+phosphocholine+hydron
Catalysed by SMPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:36087CC BY 4.0Reference data
1-O-octadecyl-sn-glycero-3-phosphocholine+water1-O-octadecyl-sn-glycerol+phosphocholine+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:39923CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycerol+phosphocholine+hydron
Catalysed by SMPD2 or ENPP6 or ENPP7 or SMPD3
Reaction pageLeft to rightBalanced
Rhea RHEA:41119CC BY 4.0Reference data
a sphingosylphosphocholine+watera sphingoid base+phosphocholine+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:45296CC BY 4.0Reference data
an N-(acyl)-sphingosylphosphocholine+wateran N-acyl-sphingoid base+phosphocholine+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:45300CC BY 4.0Reference data