Compound
1D-myo-inositol 1,4,5-trisphosphate
Hexaanion of 1D-myo-inositol 1,4,5-trisphosphate arising from glabal deprotonation of the phosphate OH groups; major species at pH 7.3.
Definition from ChEBI (CHEBI:203600), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C6H9O15P3
- Mass
- 414.045 g/mol
- Charge
- -6
- InChIKey
- MMWCIQZXVOZEGG-XJTPDSDZSA-H
- SMILES
- O=P([O-])([O-])O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)([O-])[O-])[C@H]1O
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
13 entities
13 entities reached.
0 reported hops13 assembled from the scaffold
- INPP5DProteinUNIPROT:Q92835substrate ofInferred only49 paths49 endpoints
- OCRLProteinUNIPROT:Q01968substrate ofInferred only34 paths34 endpoints
- INPP5KProteinUNIPROT:Q9BT40substrate ofInferred only22 paths11 endpoints
- SYNJ1ProteinUNIPROT:O43426substrate ofInferred only21 paths21 endpoints
- IPMKProteinUNIPROT:Q8NFU5substrate ofInferred only20 paths5 endpoints
- INPP5JProteinUNIPROT:Q15735substrate ofInferred only16 paths8 endpoints
- INPP5EProteinUNIPROT:Q9NRR6substrate ofInferred only15 paths15 endpoints
- INPP5AProteinUNIPROT:Q14642substrate ofInferred only14 paths7 endpoints
- ITPKBProteinUNIPROT:P27987substrate ofInferred only12 paths6 endpoints
- SYNJ2ProteinUNIPROT:O15056substrate ofInferred only11 paths11 endpoints
- ITPKAProteinUNIPROT:P23677substrate ofInferred only10 paths5 endpoints
- ITPKCProteinUNIPROT:Q96DU7substrate ofInferred only8 paths4 endpoints
Show the remaining 1
What the reference databases state
Statements
22 statements
22 statements · 2 reference databases · Subject: 1D-myo-inositol 1,4,5-trisphosphate · Sources: Human-GEM, Rhea
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of INPP5AProteinHuman-GEM MAR06560Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of INPP5AProteinRhea RHEA:19797Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of INPP5BProteinRhea RHEA:19797Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of INPP5DProteinRhea RHEA:19797Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of INPP5EProteinRhea RHEA:19797Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of INPP5JProteinHuman-GEM MAR06560Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of INPP5JProteinRhea RHEA:19797Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of INPP5KProteinRhea RHEA:19797Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of INPP5KProteinHuman-GEM MAR06560Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of IPMKProteinRhea RHEA:32359Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of IPMKProteinHuman-GEM MAR06573Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of IPMKProteinHuman-GEM MAR08804Inferred only
Show the remaining 10
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of IPMKProteinHuman-GEM MAR08805Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of ITPKAProteinRhea RHEA:11020Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of ITPKAProteinHuman-GEM MAR06563Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of ITPKBProteinRhea RHEA:11020Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of ITPKBProteinHuman-GEM MAR06563Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of ITPKCProteinHuman-GEM MAR06563Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of ITPKCProteinRhea RHEA:11020Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of OCRLProteinRhea RHEA:19797Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of SYNJ1ProteinRhea RHEA:19797Inferred only
- 1D-myo-inositol 1,4,5-trisphosphate is a substrate of SYNJ2ProteinRhea RHEA:19797Inferred only
Reactions
17 reactions
water+MAM02736ca 1,2-diacyl-sn-glycerol+1D-myo-inositol 1,4,5-trisphosphate+proton
Catalysed by PLCB4 or PLCH1 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCH2 or PLCB3 or PLCD3 or PLCB1 or PLCD1 and 2 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11cytosol
Human-GEM MAR06559CC BY 4.0Reference data
1D-myo-inositol 1,4,5-trisphosphate+waterMAM00526c+phosphate(3-)
Catalysed by INPP5A or INPP5K or INPP5J
Reaction pageLeft to rightBalancedEC 3.1.3.56cytosol
Human-GEM MAR06560CC BY 4.0Reference data
ATP+1D-myo-inositol 1,4,5-trisphosphateMAM00522c+ADP+proton
Catalysed by ITPKC or ITPKA or ITPKB
Reaction pageLeft to rightBalancedEC 2.7.1.127cytosol
Human-GEM MAR06563CC BY 4.0Reference data
MAM00522c+water1D-myo-inositol 1,4,5-trisphosphate+phosphate(3-)
Catalysed by MINPP1
Reaction pageLeft to rightBalancedEC 3.1.3.62cytosol
Human-GEM MAR06564CC BY 4.0Reference data
ATP+1D-myo-inositol 1,4,5-trisphosphateMAM00525c+ADP+proton
Catalysed by IPMK
Reaction pageLeft to rightBalancedEC 2.7.1.151cytosol
Human-GEM MAR06573CC BY 4.0Reference data
ATP+1D-myo-inositol 1,4,5-trisphosphateMAM00525n+ADP+proton
Catalysed by IPMK
Reaction pageLeft to rightBalancedEC 2.7.1.151nucleus
Human-GEM MAR08804CC BY 4.0Reference data
ATP+1D-myo-inositol 1,4,5-trisphosphateMAM00522n+ADP+proton
Catalysed by IPMK
Reaction pageLeft to rightBalancedEC 2.7.1.151nucleus
Human-GEM MAR08805CC BY 4.0Reference data
water+MAM02736na 1,2-diacyl-sn-glycerol+1D-myo-inositol 1,4,5-trisphosphate+proton
Catalysed by PLCB4 or PLCD4 or PLCG1 or PLCB2 or PLCE1 or PLCZ1 or PLCB3 or PLCD3 or PLCB1 or PLCD1 or PLCG2
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.11nucleus
Human-GEM MAR08818CC BY 4.0Reference data
MAM00525c+water1D-myo-inositol 1,4,5-trisphosphate+phosphate(3-)
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR10068CC BY 4.0Reference data
1D-myo-inositol 1,4,5-trisphosphate+ATP(4-)CHEBI:57895+ADP(3-)+hydron
Catalysed by ITPKA or ITPKB or ITPKC
Reaction pageLeft to rightBalanced
Rhea RHEA:11020CC BY 4.0Reference data
1D-myo-inositol 1,4,5-trisphosphate+ATP(4-)CHEBI:57627+ADP(3-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:17717CC BY 4.0Reference data
1D-myo-inositol 1,4,5-trisphosphate+waterCHEBI:58282+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5A or INPP5J or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalanced
Rhea RHEA:19797CC BY 4.0Reference data
Other names
5 names
Resolves to: 1D-myo-inositol 1,4,5-trisphosphate
- Also called
- 1D-myo-inositol 1,4,5-triphosphate hexaanion1D-myo-inositol 1,4,5-triphosphate(6-)1D-myo-inositol 1,4,5-triphosphate(6−)1D-myo-inositol 1,4,5-trisphosphate hexaanion
- Systematic name
- 1D-myo-inositol 1,4,5-tris(phosphate)