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D-mannose 6-phosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

25 compounds within 3 steps: 3 in 1, 6 in 2, 16 in 3

Does it reach a compound?

One step

alpha-D-mannose 1-phosphateReach from here →
1. alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
Catalysed by PMM2, PMM1
D-fructose 6-phosphateReach from here →
1. D-mannose 6-phosphate = D-fructose 6-phosphate
Catalysed by MPI
D-glucose 6-phosphateReach from here →
1. D-glucose 6-phosphate = D-mannose 6-phosphate
Catalysed by GPI

Two steps

NAADPHReach from here →
1. D-glucose 6-phosphate = D-mannose 6-phosphate
2. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)
Catalysed by GPI, G6PD
D-glucoseReach from here →
1. D-glucose 6-phosphate = D-mannose 6-phosphate
2. D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
Catalysed by GPI, ADPGKOne of 2 routes
6-phospho-D-glucono-1,5-lactoneReach from here →

Three steps

2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactoneReach from here →
Catalysed by MPI, GFPT2, GFPT1, H6PD
beta-D-glucoseReach from here →
Catalysed by

D-glucose 6-phosphate = D-mannose 6-phosphate

D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)

Catalysed by GPI, H6PD, G6PDOne of 3 routes

(2R)-3-phosphoglycerateReach from here →

alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate = alpha-D-mannose 1,6-bisphosphate + (2R)-3-phosphoglycerate + H(+)

Catalysed by PMM2, PMM1, PGM2L1

1D-myo-inositol 3-phosphateReach from here →

D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate

Catalysed by GPI, ISYNA1

D-glucosamine 6-phosphateReach from here →

D-mannose 6-phosphate = D-fructose 6-phosphate
D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

Catalysed by MPI, GFPT2, GFPT1

cytosol

CHEBI:16174Reach from here →

D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
dATP:D-glucose 6-phosphotransferase

Catalysed by GPI, ADPGK, HK1, HK2 and 2 morecytosol

D-glucono-1,5-lactoneReach from here →

D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
D-glucose + NAD(+) = D-glucono-1,5-lactone + NADH + H(+)

Catalysed by GPI, ADPGK, H6PDOne of 2 routes

(R)-glycerateReach from here →

alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate = alpha-D-mannose 1,6-bisphosphate + (2R)-3-phosphoglycerate + H(+)
(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)

Catalysed by PMM2, PMM1, PGM2L1, GLYCTK

myo-inositolReach from here →

D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate
1D-myo-inositol 3-phosphate phosphohydrolase

Catalysed by GPI, ISYNA1, IMPA2, IMPA1cytosolOne of 2 routes

lactoseReach from here →

D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+)

Catalysed by GPI, ADPGK, B4GALT2, B4GALT1

CHEBI:17808Reach from here →

D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
ITP:D-glucose 6-phosphotransferase

Catalysed by GPI, ADPGK, HK1, HK2 and 2 morecytosol

D-glucitolReach from here →

D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
Aldehyde Reductase

Catalysed by GPI, ADPGKcytosolOne of 3 routes

superoxideReach from here →

D-glucose 6-phosphate = D-mannose 6-phosphate
NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)
NAADPH + 2 O2 = NAADP(+) + 2 superoxide + H(+)

Catalysed by GPI, G6PD, NOX5

alpha-lactoseReach from here →

D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
UDP-alpha-D-galactose:D-glucose 4-beta-D-galactosyltransferase

Catalysed by GPI, ADPGK, B4GALT2, LALBA and 1 moreGolgi apparatus

D-glucopyranose 6-phosphateReach from here →

D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
ATP:D-glucose 6-phosphotransferase

Catalysed by GPI, ADPGK, HK1, GCK and 3 morecytosolOne of 6 routes

N-acetyl-D-glucosamine 6-phosphateReach from here →

D-mannose 6-phosphate = D-fructose 6-phosphate
D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)

Catalysed by MPI, GFPT2, GFPT1, GNPNAT1One of 2 routes

(2R)-3-phospho-glyceroyl phosphateReach from here →

alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate = alpha-D-mannose 1,6-bisphosphate + (2R)-3-phosphoglycerate + H(+)
ATP:3-phospho-D-glycerate 1-phosphotransferase

Catalysed by PMM2, PMM1, PGM2L1, PGK1 and 2 morecytosolOne of 2 routes

(2R)-2-phosphoglycerateReach from here →

alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate = alpha-D-mannose 1,6-bisphosphate + (2R)-3-phosphoglycerate + H(+)
D-phosphoglycerate 2,3-phosphomutase

Catalysed by PMM2, PMM1, PGM2L1, BPGM and 3 morecytosolOne of 2 routes

NAADP(+)Reach from here →

D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)
NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)

Catalysed by GPI, H6PD, G6PDOne of 4 routes