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Proteins/UNIPROT:O15056
Phosphatase that hydrolyzes phosphate groups from the inositol ring of phosphoinositides and inositol phosphates, in a domain-specific manner. The 5-PPase domain catalyzes removal of the 5-phosphate from substrates such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4). The SAC domain hydrolyzes phosphates at the 3- and 4-positions of the inositol ring, targeting phosphatidylinositol-3-phosphate (PI(3)P), phosphatidylinositol-4-phosphate (PI(4)P), and phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2) (By similarity). Plays a role in the phosphatidylinositol metabolic process during the early stage of clathrin-coated-pit formation. During EGF activation, plays a role in receptor-mediated endocytosis (RME) by converting PtdIns(4,5)P2 to PtdIns(4)P through the H2O2-dependent oxidation of the 4-phosphatase domain (By similarity). May play a role in tumor cell invadopodia formation..
Function from UniProtKB (O15056), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
43 statements
43 statements · 5 reference databases · Subject: SYNJ2 · Sources: Bgee, Hetionet, Reactome, Rhea, UniProt
10 reactions
water+MAM02736ca 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+phosphate(3-)
Catalysed by SYNJ2 or OCRL or INPP5E or SYNJ1 or INPP5B
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.36cytosol
Human-GEM MAR06552CC BY 4.0Reference data
water+MAM02736na 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+
6 names
Resolves to: SYNJ2
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.36nucleus
Human-GEM MAR08817CC BY 4.0Reference data
CHEBI:57895+waterCHEBI:58414+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or OCRL or INPP5A or INPP5J or INPP5D or INPP5K
Reaction pageLeft to rightBalanced
Rhea RHEA:11392CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or MTM1 or MTMR1 or MTMR2 or MTMR3 or MTMR14 or MTMR8 or SACM1L or MTMR4 or MTMR7 or MTMR6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12316CC BY 4.0Reference data
1D-myo-inositol 1,4,5-trisphosphate+waterCHEBI:58282+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5A or INPP5J or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalanced
Rhea RHEA:19797CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5J or FIG4 or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22764CC BY 4.0Reference data
CHEBI:57836+waterCHEBI:57658+hydrogenphosphate
Catalysed by SYNJ2 or INPPL1 or SYNJ1 or OCRL or FIG4 or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:25528CC BY 4.0Reference data
CHEBI:57923+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or MTM1 or MTMR1 or MTMR2 or MTMR3 or MTMR14 or MTMR8 or MTMR4 or MTMR6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:39019CC BY 4.0Reference data
CHEBI:85468+waterCHEBI:65221+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:45836CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or SACM1L or INPP5F
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:55652CC BY 4.0Reference data