a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)

1. Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase

No catalyst recordednucleusOne of 4 routes

1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate

Catalysed by SYNJ1

1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)

Catalysed by PIP4K2A, PIP4K2B, PIP4K2COne of 2 routes

1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(in) + cholesterol(out)

Catalysed by PIP4K2A, PIP4K2B, PIP4K2C, OSBP2 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

1. Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase
2. Phospholipase D

Catalysed by PLD2nucleus, cytosol

1. Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase
2. phosphoinositide phospholipase C (PI pool)
3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 15 morenucleus, cytosol

1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)(in) + cholesterol(out)
3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O