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Proteins/UNIPROT:P06744
Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm. Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P) (By similarity). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P (By similarity). In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility. Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons. Released by lectin-stimulated T-cells to induce immunoglobulin secretion..
Function from UniProtKB (P06744), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
364 statements
364 statements · 8 reference databases · Subject: GPI · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
6 reactions
keto-D-fructose 6-phosphateD-glucopyranose 6-phosphate
Catalysed by GPI
Reaction pageReversibleBalancedEC 5.3.1.9cytosol
Human-GEM MAR04381CC BY 4.0Reference data
alpha-D-glucose 6-phosphatebeta-D-fructose 6-phosphate
Catalysed by GPI
Reaction pageReversibleBalanced
Rhea RHEA:11816CC BY 4.0Reference data
alpha-D-glucose 6-phosphateCHEBI:58247
Catalysed by
12 names
Resolves to: GPI
Reaction pageReversibleBalanced
Rhea RHEA:16249CC BY 4.0Reference data
D-glucose 6-phosphateD-mannose 6-phosphate
Catalysed by GPI
Reaction pageReversibleBalanced
Rhea RHEA:85575CC BY 4.0Reference data
CHEBI:234464beta-D-fructose 6-phosphate
Catalysed by GPI
Reaction pageReversibleBalanced
Rhea RHEA:85579CC BY 4.0Reference data
CHEBI:60332CHEBI:234465
Catalysed by GPI
Reaction pageReversibleBalanced
Rhea RHEA:85583CC BY 4.0Reference data