6-phospho-D-glucono-1,5-lactone

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

30 compounds within 3 steps: 3 in 1, 7 in 2, 20 in 3

One step

D-glucopyranose 6-phosphateReach from here →
1. D-glucose-6-phosphate:NAD+ 1-oxidoreductase
Catalysed by H6PDendoplasmic reticulum
D-glucose 6-phosphateReach from here →
1. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)
Catalysed by G6PD
NAADP(+)Reach from here →
1. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)
Catalysed by G6PD

Two steps

keto-D-fructose 6-phosphateReach from here →
1. D-glucose-6-phosphate:NAD+ 1-oxidoreductase
2. D-glucose-6-phosphate aldose-ketose-isomerase
Catalysed by H6PD, GPIendoplasmic reticulum, cytosol
NAADPHReach from here →
1. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)
2. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)
Catalysed by G6PDOne of 4 routes
nicotinateReach from here →

Three steps

alpha-D-glucosamine 6-phosphateReach from here →
Catalysed by H6PD, GPI, GFPT2, GFPT1endoplasmic reticulum, cytosol
beta-D-glucoseReach from here →
Catalysed by and 1 more

NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)

2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)

Catalysed by G6PD, CD38

D-glucoseReach from here →

Catalysed by H6PD, G6PC1, G6PC3, G6PC2endoplasmic reticulumOne of 3 routes

1D-myo-inositol 3-phosphateReach from here →

Catalysed by H6PD, ISYNA1endoplasmic reticulum, cytosolOne of 2 routes

D-mannose 6-phosphateReach from here →

Catalysed by G6PD, GPI

2'-phospho-cyclic ADP-riboseReach from here →

Catalysed by G6PD, CD38

H6PD

, G6PC1

, G6PC3

, G6PC2

endoplasmic reticulum, cytosol

CHEBI:16174Reach from here →

Catalysed by H6PD, G6PC1, G6PC3, G6PC2 and 4 moreendoplasmic reticulum, cytosol

D-glucono-1,5-lactoneReach from here →

Catalysed by H6PD, G6PC1, G6PC3, G6PC2endoplasmic reticulumOne of 2 routes

CHEBI:16332Reach from here →

Catalysed by H6PD, GPI, TKT, TKTL1 and 1 moreendoplasmic reticulum, cytosol

D-erythrose 4-phosphateReach from here →

Catalysed by H6PD, GPI, TKT, TKTL1 and 1 moreendoplasmic reticulum, cytosol

nicotinamideReach from here →

Catalysed by G6PD, CD38

myo-inositolReach from here →

Catalysed by H6PD, ISYNA1, IMPA2, IMPA1endoplasmic reticulum, cytosolOne of 2 routes

lactoseReach from here →

Catalysed by H6PD, G6PC1, G6PC3, G6PC2 and 2 moreendoplasmic reticulum

urateReach from here →

Catalysed by G6PD, CD38, SLC22A12, SLC22A13inner side of the membrane, outer side of the membrane

CHEBI:17808Reach from here →

Catalysed by H6PD, G6PC1, G6PC3, G6PC2 and 4 moreendoplasmic reticulum, cytosol

D-glucitolReach from here →

Catalysed by H6PD, G6PC1, G6PC3, G6PC2endoplasmic reticulum, cytosolOne of 3 routes

superoxideReach from here →

Catalysed by G6PD, NOX5

CHEBI:29052Reach from here →

Catalysed by H6PD, GPI, TALDO1endoplasmic reticulum, cytosol

orotateReach from here →

Catalysed by G6PD, CD38, SLC22A12inner side of the membrane, outer side of the membraneOne of 2 routes

alpha-lactoseReach from here →

Catalysed by H6PD, G6PC1, G6PC3, G6PC2 and 3 moreendoplasmic reticulum, Golgi apparatus

D-sedoheptulose 7-phosphateReach from here →

Catalysed by H6PD, GPI, TALDO1endoplasmic reticulum, cytosol

nicotinate beta-D-ribonucleotideReach from here →

Catalysed by G6PD, CD38, NAPRT

alpha-D-mannose 1-phosphateReach from here →

Catalysed by G6PD, GPI, PMM2, PMM1

D-fructose 6-phosphateReach from here →

Catalysed by G6PD, GPI, MPI