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Proteins/UNIPROT:Q9NUN7
Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity)..
Function from UniProtKB (Q9NUN7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
54 statements
54 statements · 7 reference databases · Subject: ACER3 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt
30 reactions
water+an N-acyl-(4R)-4-hydroxysphinganine(4R)-hydroxysphinganine+fatty acid
Catalysed by ACER3 or ASAH1 or ACER1 or ACER2 or ASAH2
Reaction pageLeft to rightBalance undeterminableEC 3.5.1.23cytosol
Human-GEM MAR00716CC BY 4.0Reference data
6 names
Resolves to: ACER3
Reaction pageReversibleBalance undeterminableEC 3.5.1.23cytosol
Human-GEM MAR00753CC BY 4.0Reference data
water+N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine(5Z,8Z,11Z,14Z)-eicosatetraenoate+CHEBI:16566
Catalysed by ACER3
Reaction pageLeft to rightBalancedEC 3.5.1.23endoplasmic reticulum
Human-GEM MAR20073CC BY 4.0Reference data
water+N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine(5Z,8Z,11Z,14Z)-eicosatetraenoate+CHEBI:16566
Catalysed by ACER3
Reaction pageLeft to rightBalancedEC 3.5.1.23Golgi apparatus
Human-GEM MAR20074CC BY 4.0Reference data
water+N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine(5Z,8Z,11Z,14Z)-eicosatetraenoate+(4R)-hydroxysphinganine
Catalysed by ACER3
Reaction pageLeft to rightBalancedEC 3.5.1.23endoplasmic reticulum
Human-GEM MAR20075CC BY 4.0Reference data
water+N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine(5Z,8Z,11Z,14Z)-eicosatetraenoate+(4R)-hydroxysphinganine
Catalysed by ACER3
Reaction pageLeft to rightBalancedEC 3.5.1.23Golgi apparatus
Human-GEM MAR20076CC BY 4.0Reference data
water+N-(11Z-eicosenoyl)-sphing-4-enine(11Z)-eicosenoate+sphing-4-enine
Catalysed by ACER3
Reaction pageLeft to rightBalancedEC 3.5.1.23endoplasmic reticulum
Human-GEM MAR20077CC BY 4.0Reference data
water+N-(11Z-eicosenoyl)-sphing-4-enine(11Z)-eicosenoate+sphing-4-enine
Catalysed by ACER3
Reaction pageLeft to rightBalancedEC 3.5.1.23Golgi apparatus
Human-GEM MAR20078CC BY 4.0Reference data
water+N-(11Z-eicosenoyl)-sphinganine(11Z)-eicosenoate+CHEBI:16566
Catalysed by ACER3
Reaction pageLeft to rightBalancedEC 3.5.1.23endoplasmic reticulum
Human-GEM MAR20079CC BY 4.0Reference data
water+N-(11Z-eicosenoyl)-sphinganine(11Z)-eicosenoate+CHEBI:16566
Catalysed by ACER3
Reaction pageLeft to rightBalancedEC 3.5.1.23Golgi apparatus
Human-GEM MAR20080CC BY 4.0Reference data
water+N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine(11Z)-eicosenoate+(4R)-hydroxysphinganine
Catalysed by ACER3
Reaction pageLeft to rightBalancedEC 3.5.1.23endoplasmic reticulum
Human-GEM MAR20081CC BY 4.0Reference data
water+N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine(11Z)-eicosenoate+(4R)-hydroxysphinganine
Catalysed by ACER3
Reaction pageLeft to rightBalancedEC 3.5.1.23Golgi apparatus
Human-GEM MAR20082CC BY 4.0Reference data