Loading the page.
Proteins/UNIPROT:Q9H227
Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Hydrolyzes galactosylceramides/GalCers, glucosylsphingosines/GlcSphs and galactosylsphingosines/GalSphs. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics. Possesses transxylosylase activity in vitro using xylosylated ceramides/XylCers (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) as xylosyl donors and cholesterol as acceptor. Could also play a role in the catabolism of cytosolic sialyl free N-glycans..
Function from UniProtKB (Q9H227), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
19 statements
19 statements · 4 reference databases · Subject: GBA3 · Sources: Hetionet, Human-GEM, Reactome, Rhea
9 reactions
D-glucosyl-N-acylsphingosine+wateran N-acylsphing-4-enine+D-glucose
Catalysed by GBA2 or GBA1 or GBA3
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.45cytosol
Human-GEM MAR00762CC BY 4.0Reference data
cis-beta-D-glucosyl-2-hydroxycinnamate+watercis-2-coumarate+D-glucose+proton
Catalysed by
11 names
Resolves to: GBA3
Reaction pageLeft to rightBalancedEC 3.2.1.21cytosol
Human-GEM MAR09555CC BY 4.0Reference data
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine+wateran N-acylsphing-4-enine+D-glucose
Catalysed by GBA1 or GBA3 or GBA2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:13269CC BY 4.0Reference data
a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine+waterD-galactose+an N-acylsphing-4-enine
Catalysed by GBA1 or GALC or GBA3 or GBA2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:14297CC BY 4.0Reference data
beta-D-galactosyl-(1<->1)-sphing-4-enine+watersphing-4-enine+D-galactose
Reaction pageLeft to rightBalanced
Rhea RHEA:43908CC BY 4.0Reference data
beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine+waterN-octadecanoylsphing-4-enine+D-glucose
Catalysed by GBA3
Reaction pageLeft to rightBalanced
Rhea RHEA:59284CC BY 4.0Reference data
beta-D-glucosyl-(1<->1)-sphing-4-enine+watersphing-4-enine+D-glucose
Catalysed by GBA3
Reaction pageLeft to rightBalanced
Rhea RHEA:59288CC BY 4.0Reference data
beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine+waterN-octadecanoylsphing-4-enine+D-galactose
Catalysed by GBA3
Reaction pageLeft to rightBalanced
Rhea RHEA:59292CC BY 4.0Reference data
a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine+cholesterolcholesteryl 3-beta-D-xyloside+an N-acylsphing-4-enine
Reaction pageReversibleBalance undeterminable
Rhea RHEA:70239CC BY 4.0Reference data