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Proteins/UNIPROT:Q16880
Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (By similarity)..
Function from UniProtKB (Q16880), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
60 statements
60 statements · 7 reference databases · Subject: UGT8 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
an N-acylsphing-4-enine+CHEBI:67119CHEBI:12947+proton+UDP
Catalysed by UGT8
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.47cytosol
Human-GEM MAR00919CC BY 4.0Reference data
an N-acylsphing-4-enine+CHEBI:67119CHEBI:12947+proton+UDP
Catalysed by UGT8
5 names
Resolves to: UGT8
Human-GEM MAR00920CC BY 4.0Reference data
an N-acylsphing-4-enine+CHEBI:67119CHEBI:12947+proton+UDP
Catalysed by UGT8
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.47endoplasmic reticulum
Human-GEM MAR00921CC BY 4.0Reference data
an N-acylsphing-4-enine+UDP-alpha-D-galactosea beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine+UDP+hydron
Catalysed by UGT8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:13093CC BY 4.0Reference data
N-(2-hydroxy-hexanoyl)-sphing-4-enine+UDP-alpha-D-galactoseN-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine+UDP+hydron
Catalysed by UGT8
Reaction pageLeft to rightBalanced
Rhea RHEA:43400CC BY 4.0Reference data
N-(2-hydroxy-hexanoyl)-sphinganine+UDP-alpha-D-galactoseN-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine+UDP+hydron
Catalysed by UGT8
Reaction pageLeft to rightBalanced
Rhea RHEA:43404CC BY 4.0Reference data
an N-acyl-sphingoid base+UDP-alpha-D-galactosea beta-D-Gal-(1<->1')-ceramide+UDP+hydron
Catalysed by UGT8
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:48344CC BY 4.0Reference data