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Proteins/UNIPROT:Q13822
Secreted lysophospholipase D that hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Its major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (Probable). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF)..
Function from UniProtKB (Q13822), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
121 statements
121 statements · 7 reference databases · Subject: ENPP2 · Sources: Bgee, gene ontology, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
26 reactions
1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamine+proton+waterMAM00222c+ethanolamine
Catalysed by ENPP2
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.39cytosol
Human-GEM MAR07607CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1,2-diacyl-sn-glycero-3-phosphate+choline+hydron
Catalysed by PLD2
6 names
Resolves to: ENPP2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:14445CC BY 4.0Reference data
a 1-O-alkyl-sn-glycero-3-phosphoethanolamine+watera 1-O-alkyl-sn-glycero-3-phosphate+ethanolamine+hydron
Catalysed by ENPP2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15965CC BY 4.0Reference data
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water1-(9Z-octadecenoyl)-sn-glycero-3-phosphate+choline+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:38915CC BY 4.0Reference data
sphing-4-enine-phosphocholine+watersphing-4-enine 1-phosphate+choline+hydron
Catalysed by ENPP2
Reaction pageLeft to rightBalanced
Rhea RHEA:38919CC BY 4.0Reference data
1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+water1-(9Z-octadecenoyl)-sn-glycero-3-phosphate+ethanolamine+hydron
Catalysed by ENPP2
Reaction pageLeft to rightBalanced
Rhea RHEA:38927CC BY 4.0Reference data
1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine+water1-(9Z-octadecenoyl)-sn-glycero-3-phosphate+L-seryl residue+hydron
Catalysed by ENPP2
Reaction pageLeft to rightBalanced
Rhea RHEA:38931CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphate+choline+hydron
Catalysed by ENPP2 or GDPD3 or GDPD1
Reaction pageLeft to rightBalanced
Rhea RHEA:38975CC BY 4.0Reference data
1-octadecanoyl-sn-glycero-3-phosphocholine+water1-octadecanoyl-sn-glycero-3-phosphate+choline+hydron
Catalysed by ENPP2
Reaction pageLeft to rightBalanced
Rhea RHEA:38979CC BY 4.0Reference data
1-tetradecanoyl-sn-glycero-3-phosphocholine+water1-tetradecanoyl-sn-glycerol 3-phosphate+choline+hydron
Catalysed by ENPP2
Reaction pageLeft to rightBalanced
Rhea RHEA:38983CC BY 4.0Reference data
1-dodecanoyl-sn-glycero-3-phosphocholine+water1-dodecanoyl-sn-glycerol 3-phosphate+choline+hydron
Catalysed by ENPP2
Reaction pageLeft to rightBalanced
Rhea RHEA:38991CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphate+choline+hydron
Catalysed by ENPP2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:38995CC BY 4.0Reference data