Compound

pregn-5-ene-3,20-dione

A C21-steroid that is pregnane which contains a double bond between positions 5 and 6 and is substituted by oxo groups at positions 3 and 20.

Definition from ChEBI (CHEBI:63837), read 2026-09-23. CC BY 4.0.

CHEBI:63837ChEBI

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Structure

2D depiction · 3D model shown

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A generated conformer of pregn-5-ene-3,20-dione — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound
Formula: C21H30O2
Mass: 314.469 g/mol
Charge: 0
InChIKey: MNRHZPCIEGLWGK-LEKSSAKUSA-N
SMILES: [H][C@@]12CC=C3CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](C(C)=O)CC[C@@]21[H]
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

3 entities

3 entities reached.

0 reported hops3 assembled from the scaffold

What the reference databases state

Statements

9 statements

9 statements · 2 reference databases · Subject: pregn-5-ene-3,20-dione · Sources: Human-GEM, Rhea

Order

pregnenolone is converted to pregn-5-ene-3,20-dioneCompoundHuman-GEM MAR01979Inferred only
pregnenolone is converted to pregn-5-ene-3,20-dioneCompoundRhea RHEA:43924Inferred only
pregn-5-ene-3,20-dione is converted to progesteroneCompoundHuman-GEM MAR01980Inferred only
pregn-5-ene-3,20-dione is converted to progesteroneCompoundRhea RHEA:43928Inferred only
pregn-5-ene-3,20-dione is metabolised by GSTA3ProteinRhea RHEA:43928Inferred only
pregn-5-ene-3,20-dione is a substrate of HSD3B1ProteinHuman-GEM MAR01980Inferred only
pregn-5-ene-3,20-dione is a substrate of HSD3B1ProteinRhea RHEA:43928Inferred only
pregn-5-ene-3,20-dione is a substrate of HSD3B2ProteinRhea RHEA:43928Inferred only
pregn-5-ene-3,20-dione is a substrate of HSD3B2ProteinHuman-GEM MAR01980Inferred only

Reactions

4 reactions

NAD(+)+pregnenoloneproton+NADH(2-)+pregn-5-ene-3,20-dione
Catalysed by HSD3B1 or HSD3B2
Reaction pageLeft to rightBalancedEC 1.1.1.145cytosol
Human-GEM MAR01979CC BY 4.0Reference data
pregn-5-ene-3,20-dioneprogesterone
Catalysed by HSD3B1 or HSD3B2
Reaction pageLeft to rightBalancedEC 5.3.3.1cytosol
Human-GEM MAR01980CC BY 4.0Reference data
pregnenolone+NAD(1-)pregn-5-ene-3,20-dione+NADH(2-)+hydron
Catalysed by HSD3B1 or HSD3B2
Reaction pageLeft to rightBalanced
Rhea RHEA:43924CC BY 4.0Reference data
pregn-5-ene-3,20-dioneprogesterone
Catalysed by HSD3B1 or HSD3B2 or GSTA3
Reaction pageLeft to rightBalanced
Rhea RHEA:43928CC BY 4.0Reference data

Other names

3 names

Resolves to: pregn-5-ene-3,20-dione

Also called: 5-pregnene-3,20-dioneisoprogesteroneST 21:3;O2