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Proteins/UNIPROT:O43286
Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity)..
Function from UniProtKB (O43286), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
66 statements
66 statements · 8 reference databases · Subject: B4GALT5 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
27 reactions
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or PIGV or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 23 more alternatives
9 names
Resolves to: B4GALT5
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR00765CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694c+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 10 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00924CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694g+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or POMGNT1 or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 16 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR00925CC BY 4.0Reference data
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00926CC BY 4.0Reference data
MAM01871g+CHEBI:67119MAM01872g+proton+UDP
Catalysed by B4GALT5
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR07181CC BY 4.0Reference data
MAM01829g+2CHEBI:671192proton+MAM02323g+2UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.38Golgi apparatus
Human-GEM MAR07333CC BY 4.0Reference data
MAM02212g+CHEBI:67119proton+MAM02223g+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR07337CC BY 4.0Reference data
MAM02232g+CHEBI:67119proton+MAM02233g+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR07340CC BY 4.0Reference data
MAM02235g+CHEBI:67119proton+MAM02236g+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR07343CC BY 4.0Reference data
MAM02203g+CHEBI:67119proton+MAM02204g+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR07346CC BY 4.0Reference data
MAM02206g+CHEBI:67119proton+MAM02207g+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR07349CC BY 4.0Reference data
MAM02209g+CHEBI:67119proton+MAM02210g+UDP
Catalysed by B4GALT1 or B4GALT2 or B4GALT5 or B4GALT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR07352CC BY 4.0Reference data