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Proteins/UNIPROT:O60218
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no reductase activity towards glucose..
Function from UniProtKB (O60218), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
129 statements
129 statements · 7 reference databases · Subject: AKR1B10 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
21 reactions
8 names
Resolves to: AKR1B10
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.2, 1.1.1.21, 1.1.1.72mitochondrial matrix
Human-GEM MAR00458CC BY 4.0Reference data
MAM00339c+NADP(3-)MAM00394c+proton+NADPH(4-)
Catalysed by HSD3B7 or DHRS2 or HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or SDR42E2 and 10 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR01098CC BY 4.0Reference data
MAM00747r+proton+NADPH(4-)MAM01087r+NADP(3-)
Catalysed by HSD17B14 or HSD3B7 or DHRS2 or HTATIP2 or RDH10 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 and 12 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-endoplasmic reticulum
Human-GEM MAR01813CC BY 4.0Reference data
proton+4-methylpentanal+NADPH(4-)4-methylpentan-1-ol+NADP(3-)
Catalysed by AKR1B1 or AKR1B10
Reaction pageLeft to rightBalancedEC 1.1.1.21cytosol
Human-GEM MAR01931CC BY 4.0Reference data
proton+methylglyoxal+NADH(2-)MAM02329c+NAD(+)
Catalysed by AKR1B1 or AKR1B10
Reaction pageLeft to rightBalancedEC 1.1.1.21cytosol
Human-GEM MAR03854CC BY 4.0Reference data
proton+MAM02329c+NADPH(4-)NADP(3-)+propane-1,2-diol
Catalysed by AKR1B1 or AKR1B10
Reaction pageLeft to rightBalancedEC 1.1.1.21cytosol
Human-GEM MAR03855CC BY 4.0Reference data
MAM01029c+proton+NADPH(4-)MAM01229c+NADP(3-)
Catalysed by HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or RDH13 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or HSD11B2 or SDR42E2 and 10 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR06670CC BY 4.0Reference data
4-methyl-2-oxopentanoate+proton+NADH(2-)2-hydroxy-4-methylvaleric acid+NAD(+)
Catalysed by DHRS2 or HTATIP2 or MDH1B or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or SDR42E2 or SDR42E1 or WWOX and 6 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR06925CC BY 4.0Reference data
MAM00799m+NADP(3-)proton+NADPH(4-)+MAM03168m
Catalysed by DHRS2 or HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 or SDR42E2 or SDR42E1 or WWOX and 7 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-mitochondrial matrix
Human-GEM MAR09804CC BY 4.0Reference data
CHEBI:16605+NADP(3-)CHEBI:15368+NADPH(4-)+hydron
Catalysed by AKR1B15 or AKR1B10 or AKR1A1 or AKR1B1
Reaction pageDirection not assertedBalanced
Rhea RHEA:12168CC BY 4.0Reference data
all-trans-retinol+NADP(3-)all-trans-retinal+NADPH(4-)+hydron
Catalysed by AKR1B15 or AKR1B10 or DHRS3 or AKR1B1 or RDH10 or RDH13 or RDH11 or RDH12 or RDH14 or RDH8 or DHRS7
Reaction pageRight to leftBalanced
Rhea RHEA:25033CC BY 4.0Reference data