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Proteins/UNIPROT:P11413
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. Also catalyzes the conversion of NAADPH, which is produced by enzymes such as DUOX1, DUOX2 and NOX5 from NAADP and promotes Ca(2+) signaling during T cell activation, back to NAADP..
Function from UniProtKB (P11413), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
265 statements
265 statements · 8 reference databases · Subject: G6PD · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
D-glucopyranose 6-phosphate+NADP(3-)6-phospho-D-glucono-1,5-lactone+proton+NADPH(4-)
Catalysed by G6PD
Reaction pageLeft to rightBalancedEC 1.1.1.49endoplasmic reticulum
Human-GEM MAR04304CC BY 4.0Reference data
D-glucopyranose 6-phosphate+NADP(3-)6-phospho-D-glucono-1,5-lactone+proton+NADPH(4-)
Catalysed by
Reaction pageLeft to rightBalancedEC 1.1.1.49cytosol
Human-GEM MAR08971CC BY 4.0Reference data
D-glucose 6-phosphate+NADP(3-)6-phospho-D-glucono-1,5-lactone+NADPH(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:15841CC BY 4.0Reference data
NAADP(+)+D-glucose 6-phosphateNAADPH+6-phospho-D-glucono-1,5-lactone+hydron
Catalysed by G6PD
Reaction pageDirection not assertedBalanced
Rhea RHEA:86243CC BY 4.0Reference data