3-fumarylpyruvate

Three steps

• 4-maleylacetoacetateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)
  3. 4-maleylacetoacetate = 4-fumarylacetoacetate

  Catalysed by FAHD1, FAH, GSTZ1

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by FAHD1, NPLcytosolOne of 2 routes

• L-isoleucineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and isoleucine (cytosol to extracellular)

  Catalysed by FAHD1, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• CHEBI:17203Reach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and proline (cytosol to extracellular)

  Catalysed by FAHD1, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol, endoplasmic reticulum

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. a quinone + succinate = fumarate + a quinol
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by FAHD1, SDHB, PRODH, PRODH2

• enol-oxaloacetateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by FAHD1, ME2, SDHB, SDHAOne of 3 routes

• AH2Reach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by FAHD1, AGXT2, MOCOSmitochondrial matrixOne of 7 routes

• L-cysteineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and cysteine (cytosol to extracellular)

  Catalysed by FAHD1, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 21 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. Steryl-Sulfatase

  Catalysed by FAHD1, SLC25A10, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by FAHD1, AGXT2, AARS1mitochondrial matrix, cytosol

• 4-methylumbelliferyl acetateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 5 moreextracellular space, cytosol

• urateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (S)-Lactate:NAD+ oxidoreductase
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by FAHD1, LDHB, LDHAL6B, SLC22A12mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:17895Reach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and tyrosine (cytosol to extracellular)

  Catalysed by FAHD1, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 8 routes

• all-trans-retinalReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• ubiquinolReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. succinate:quinone oxidoreductase
  3. thioredoxin-disulfide reductase (NADPH) (ubiquinone)

  Catalysed by FAHD1, SDHD, SDHB, SDHA and 3 moremitochondrial matrix, cytosolOne of 6 routes

• 3-phenylpyruvateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

  Catalysed by FAHD1, KYAT1cytosol

• CHEBI:18019Reach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and lysine (cytosol to extracellular)

  Catalysed by FAHD1, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• thiocyanateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)

  Catalysed by FAHD1, MPST, TSTcytosolOne of 3 routes

• L-glutamineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and glutamine (cytosol to extracellular)

  Catalysed by FAHD1, AGXT2, SLC3A2, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 17 routes

• dTTPReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. pyruvate kinase (dTDP)
  3. DTTP Nucleotidohydrolase

  Catalysed by FAHD1, PKM, PKLR, ENTPD3 and 2 morecytosol, extracellular spaceOne of 11 routes

• CHEBI:18095Reach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of Hydroxy-Proline

  Catalysed by FAHD1, AGXT2, SLC1A4mitochondrial matrix, extracellular space, cytosol

• hydrogen cyanideReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by FAHD1, SLC25A10, MPST, TSTmitochondrial matrix, cytosolOne of 2 routes

• S-methylmercury-L-cysteineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by FAHD1, TYW1B, TYW1, SLC7A8inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by FAHD1, AGXT2, BCKDHA, BCKDHBmitochondrial matrix

• 2-aminoisobutanoateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by FAHD1, AGXT2, SLC7A10mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-isoleucineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. D-serine = pyruvate + NH4(+)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by FAHD1, SRR, SLC7A10inner side of the membrane, outer side of the membrane

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by FAHD1, AGXT2mitochondrial matrixOne of 3 routes

• (S)-lactoyl-AMPReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

  Catalysed by FAHD1, LDHA, LDHB, LDHC and 4 more

• (S)-lactoyl-CoAReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + CoA = (S)-lactoyl-CoA + AMP + diphosphate

  Catalysed by FAHD1, LDHA, LDHB, LDHC and 3 more

• N-acetylneuraminate 9-phosphateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. pyruvate kinase (dTDP)
  3. N-acetylneuraminate synthase

  Catalysed by FAHD1, PKM, PKLR, NANScytosol

• a quinolReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by FAHD1, ME2, SDHB, SDHAOne of 13 routes

• folic acidReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. Folate Transport by Oats

  Catalysed by FAHD1, SLC25A10, SLC22A8, SLC22A7mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• selenomethionineReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by FAHD1, AGXT2, CTHcytosol

• CHEBI:27760Reach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by FAHD1, AGXT2, CTHcytosol

• 3-mercaptolactic acidReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-Mercaptolactate:NAD+ oxidoreductase

  Catalysed by FAHD1, MPST, LDHB, LDHC and 2 morecytosol

• 2-oxopentanoateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by FAHD1, AGXT2

• 17alpha-hydroxypregnenoloneReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol, endoplasmic reticulum

• pyridoxine 5'-phosphateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by FAHD1, AGXT2, SCLYmitochondrial matrix, cytosol

• a dicarboxylateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by FAHD1, SLC25A10, SLC25A35, SLC25A34mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-glycoloylneuraminateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CMP-N-acetylneuraminate monooxygenase (N-acetylneuraminate)

  Catalysed by FAHD1, NPLcytosol

• a carboxylateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by FAHD1

• chlorine(.)Reach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by FAHD1, AGXT2, SLC6A14mitochondrial matrix, extracellular space, cytosolOne of 7 routes

• hydrogen sulfideReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by FAHD1, MPSTOne of 3 routes

• D-aspartateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by FAHD1, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by FAHD1, AGXT2mitochondrial matrixOne of 12 routes

• oxalateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by FAHD1, SLC25A10, SLC25A14, SLC26A2 and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• citric acidReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by FAHD1, PC, CSmitochondrial matrixOne of 9 routes

• maleateReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by FAHD1, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. transport of malonate and sulfite (cytosol to mitochondria)

  Catalysed by FAHD1, SLC25A10mitochondrial matrix, cytosolOne of 4 routes