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Proteins/UNIPROT:P04040
Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells..
Function from UniProtKB (P04040), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
301 statements
301 statements · 6 reference databases · Subject: CAT · Sources: gene ontology, Hetionet, Human-GEM, Reactome, UniProt, WikiPathways · Rows fetched: 300
7 reactions
2hydrogen peroxide2water+dioxygen
Catalysed by CAT
Reaction pageLeft to rightBalancedEC 1.11.1.6cytosol
Human-GEM MAR03980CC BY 4.0Reference data
2hydrogen peroxide2water+dioxygen
Catalysed by CAT
Reaction pageLeft to rightBalancedEC 1.11.1.6mitochondrial matrix
Human-GEM MAR03982CC BY 4.0Reference data
3 papers
Natamycin Has an Inhibitory Effect on Neofusicoccum parvum, the Pathogen of Chestnuts.record2023PMID:371751191 finding
Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling.record2020PMID:313726561 finding
Biochemical responses and mitochondrial mediated activation of apoptosis on long-term effect of aspartame in rat brain.record2014PMID:250097841 finding
1 name
Resolves to: CAT
2hydrogen peroxide2water+dioxygen
Reaction pageLeft to rightBalancedEC 1.11.1.6peroxisome
Human-GEM MAR03984CC BY 4.0Reference data
hydrogen peroxide+methanolformaldehyde+2water
Catalysed by PRDX6 or EPX or CAT or PXDN or LPO
Reaction pageLeft to rightBalancedEC 1.11.1.6, 1.11.1.7cytosol
Human-GEM MAR04201CC BY 4.0Reference data
23-hydroxyanthranilic acid+4dioxygenMAM01572c+4proton+2hydrogen peroxide+2superoxide
Catalysed by CAT
Reaction pageLeft to rightBalancedEC 1.11.1.6cytosol
Human-GEM MAR04227CC BY 4.0Reference data
ethanol+hydrogen peroxideacetaldehyde+2water
Catalysed by CAT
Reaction pageLeft to rightBalancedEC 1.11.1.6peroxisome
Human-GEM MAR08360CC BY 4.0Reference data
2hydrogen peroxidedioxygen+2water
Catalysed by CAT
Reaction pageDirection not assertedBalanced
Rhea RHEA:20309CC BY 4.0Reference data