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Proteins/UNIPROT:Q9UGL1
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity)..
Function from UniProtKB (Q9UGL1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
122 statements
122 statements · 8 reference databases · Subject: KDM5B · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, Rhea, UniProt, WikiPathways
1 reaction
N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3]+32-oxoglutarate(2-)+3dioxygenL-lysyl(4)-[histone H3]+3formaldehyde+3succinate(2-)+3carbon dioxide
Catalysed by KDM5A or KDM5C or KDM5D or KDM5B
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:60208CC BY 4.0Reference data
11 names
Resolves to: KDM5B