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Proteins/UNIPROT:Q9UK23
Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases..
Function from UniProtKB (Q9UK23), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
59 statements
59 statements · 3 reference databases · Subject: NAGPA · Sources: Hetionet, Human-GEM, Rhea
2 reactions
MAM02002c+waterMAM02003c+N-acetyl-D-glucosamine
Catalysed by NAGPA
Reaction pageReversibleBalance undeterminableEC 3.1.4.45cytosol
Human-GEM MAR09548CC BY 4.0Reference data
N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein]+waterN(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein]+N-acetyl-D-glucosamine+hydron
Catalysed by NAGPA
2 names
Resolves to: NAGPA
Rhea RHEA:24372CC BY 4.0Reference data