Proteins/UNIPROT:Q5U5Q3

MEX3C

ProteinUNIPROT:Q5U5Q3

E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation..

Function from UniProtKB (Q5U5Q3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 2 reference databases · Subject: MEX3C · Sources: Hetionet, Reactome

Order

B2M interacts with MEX3CProteinHetionet hetionet:interacts:51320-567Inferred only
CDX2 interacts with MEX3CProteinHetionet hetionet:interacts:1045-51320Inferred only
GAPDH interacts with MEX3CProteinHetionet hetionet:interacts:2597-51320Inferred only
HLA-A interacts with MEX3CProteinHetionet hetionet:interacts:3105-51320Inferred only
PABPC1 interacts with MEX3CProteinHetionet hetionet:interacts:26986-51320Inferred only
UBC interacts with MEX3CProteinHetionet hetionet:interacts:51320-7316Inferred only
USP7 interacts with MEX3CProteinHetionet hetionet:interacts:51320-7874Inferred only
MEX3C participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
MEX3C participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
MEX3C participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
MEX3C participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
AKAP8 decreases the expression of MEX3CProteinHetionet hetionet:regulates:10270-51320Inferred only

Show the remaining 5

CAT increases the expression of MEX3CProteinHetionet hetionet:regulates:847-51320Inferred only
DAP increases the expression of MEX3CProteinHetionet hetionet:regulates:1611-51320Inferred only
GM2A decreases the expression of MEX3CProteinHetionet hetionet:regulates:2760-51320Inferred only
GSTM2 increases the expression of MEX3CProteinHetionet hetionet:regulates:2946-51320Inferred only
SMARCB1 increases the expression of MEX3CProteinHetionet hetionet:regulates:6598-51320Inferred only

Other names

5 names

Resolves to: MEX3C

Also called: RING finger and KH domain-containing protein 2RING finger protein 194RING-type E3 ubiquitin transferase MEX3CRKHD2RNF194

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