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Proteins/UNIPROT:O75521
Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids. Together with the 2,4-dienoyl-CoA reductase (DECR) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH), they allow the reentrance of the enoyl-CoA into the beta-oxidation cycle. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of fatty enoyl-CoA species, with a preference for (3E)-enoyl-CoAs over (3Z)-enoyl-CoAs. Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (Probable)..
Function from UniProtKB (O75521), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
56 statements
56 statements · 3 reference databases · Subject: ECI2 · Sources: Hetionet, Human-GEM, Rhea
73 reactions
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA+CHEBI:1146900+water+NAD(+)(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA+CHEBI:15351+proton+NADH(2-)
Catalysed by ACADL & HADHA & ECI1 & HADHB & ECH1 & DECR1 or ECI2 & ACADL & HADHA & HADHB &
12 names
Resolves to: ECI2
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00970CC BY 4.0Reference data
MAM01119x+waterMAM00689x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR01164CC BY 4.0Reference data
MAM01121x+waterMAM00690x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR01207CC BY 4.0Reference data
MAM00026x+waterMAM00581x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR01256CC BY 4.0Reference data
MAM01037x+waterMAM00691x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR01273CC BY 4.0Reference data
MAM00027x+waterMAM00419x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR01292CC BY 4.0Reference data
MAM00401xMAM00422x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageReversibleBalancedEC 5.3.3.8peroxisome
Human-GEM MAR01298CC BY 4.0Reference data
MAM00401x+waterMAM00397x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR01299CC BY 4.0Reference data
water+MAM03028xMAM00717x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR02409CC BY 4.0Reference data
MAM01664x+waterMAM00801x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR02511CC BY 4.0Reference data
(2E)-tetracosenoyl-CoA+waterMAM00800x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR03063CC BY 4.0Reference data
(2E)-eicosenoyl-CoA+waterMAM00777x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR03071CC BY 4.0Reference data