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Proteins/UNIPROT:P25963
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription..
Function from UniProtKB (P25963), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
529 statements
529 statements · 4 reference databases · Subject: NFKBIA · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
7 names
Resolves to: NFKBIA