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Proteins/UNIPROT:Q96RD7
Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis. Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (By similarity). Can release ATP upon activation through phosphorylation or cleavage at C-terminus. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis..
[Caspase-activated pannexin-1]: During apoptosis, the C terminal tail is cleaved by caspases, which opens the main pore acting as a large-pore ATP efflux channel with a broad distribution, which allows the regulated release of molecules and ions smaller than 1 kDa, such as nucleotides ATP and UTP, and selective plasma membrane permeability to attract phagocytes that engulf the dying cells..
Function from UniProtKB (Q96RD7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
72 statements
72 statements · 5 reference databases · Subject: PANX1 · Sources: gene ontology, Hetionet, Reactome, Rhea, WikiPathways
11 reactions
3 names
Resolves to: PANX1
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data
Transported by GABRR3 or GPHRA or KCNK1 or CLIC1 or GABRP or CLDN4 or GABRD or CLIC2 or SLC26A4 or GLRA3 or BEST1 or KCNK2 and 69 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29823CC BY 4.0Reference data
Transported by CLIC1 or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN17 or CLDN10 or AQP6 or SLC1A5 or SLC5A8 or SLC26A7 and 3 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:34923CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A1 or SLC22A3 or SLC45A4 or SLC22A16 or PANX1
Reaction pageDirection not assertedBalanced
Rhea RHEA:35039CC BY 4.0Reference data
Transported by GPHRA or CLIC1 or CLDN4 or SLC26A4 or GPHRB or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 and 14 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:66324CC BY 4.0Reference data
Transported by SLC38A8 or SLC25A14 or UCP2 or LRRC8A or PANX1 or SLC17A5
Reaction pageLeft to rightBalanced
Rhea RHEA:66332CC BY 4.0Reference data
L-glutamate(1-)L-glutamate(1-)
Transported by KCNK1 or BEST1 or KCNK2 or SLC25A14 or VDAC1 or LRRC8A or SLC38A6 or SLC17A8 or BEST2 or PANX1 or TTYH2 or TTYH3 and 5 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:66336CC BY 4.0Reference data
Transported by VDAC1 or CALHM6 or CALHM3 or CALHM1 or PANX3 or PANX2 or PANX1 or SLC17A9 or SLC29A3 or CALHM2 or ANKH
Reaction pageLeft to rightBalanced
Rhea RHEA:75687CC BY 4.0Reference data
Transported by SLC26A7 or PANX2 or PANX1
Reaction pageDirection not assertedBalanced
Rhea RHEA:76139CC BY 4.0Reference data