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Proteins/UNIPROT:P53004
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Does not reduce bilirubin IXbeta. Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems..
Function from UniProtKB (P53004), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
440 statements
440 statements · 7 reference databases · Subject: BLVRA · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
4 reactions
biliverdin IXalpha+proton+NADH(2-)bilirubin IXalpha+NAD(+)
Reaction pageLeft to rightBalancedEC 1.3.1.24cytosol
Human-GEM MAR04764CC BY 4.0Reference data
biliverdin IXalpha+proton+NADPH(4-)bilirubin IXalpha+NADP(3-)
Catalysed by
4 names
Resolves to: BLVRA
Reaction pageLeft to rightBalancedEC 1.5.1.30, 1.3.1.24cytosol
Human-GEM MAR08634CC BY 4.0Reference data
(4Z,15Z)-bilirubin IXalpha+NADP(3-)biliverdin IXalpha+NADPH(4-)+hydron
Catalysed by BLVRA
Reaction pageRight to leftBalanced
Rhea RHEA:15793CC BY 4.0Reference data
(4Z,15Z)-bilirubin IXalpha+NAD(1-)biliverdin IXalpha+NADH(2-)+hydron
Catalysed by BLVRA
Reaction pageRight to leftBalanced
Rhea RHEA:15797CC BY 4.0Reference data