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Proteins/UNIPROT:Q92692
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein..
(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV)..
Function from UniProtKB (Q92692), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
75 statements
75 statements · 4 reference databases · Subject: NECTIN2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
8 names
Resolves to: NECTIN2