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Proteins/UNIPROT:P08910
Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation. May also play a role in smooth muscle cells migration (By similarity)..
Function from UniProtKB (P08910), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
90 statements
90 statements · 4 reference databases · Subject: ABHD2 · Sources: Bgee, Hetionet, Rhea, WikiPathways
5 reactions
a triacylglycerol+watera diacylglycerol+a fatty acid+hydron
Catalysed by DDHD2 or LPL or LIPF or ABHD2 or LIPC or PNLIP or CEL or AADAC or PNPLA4 or PNLIPRP2 or LIPE or PNLIPRP3 and 7 more alternatives
8 names
Resolves to: ABHD2
Rhea RHEA:12044CC BY 4.0Reference data
an acetyl ester+wateran aliphatic alcohol+acetate+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12957CC BY 4.0Reference data
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+waterglycerol+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron
Catalysed by FAAH or CES2 or ABHD16A or EPHX1 or ABHD2 or CES1 or LIPE or PNPLA6 or ABHD12 or MGLL or ABHD6
Reaction pageLeft to rightBalanced
Rhea RHEA:26132CC BY 4.0Reference data
a butanoate ester+wateran aliphatic alcohol+butanoate+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47348CC BY 4.0Reference data
hexadecanoate ester+wateran aliphatic alcohol+hexadecanoate+hydron
Catalysed by ABHD2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47392CC BY 4.0Reference data