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Proteins/UNIPROT:Q96GC6
Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions..
Function from UniProtKB (Q96GC6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
217 statements
217 statements · 3 reference databases · Subject: ZNF274 · Sources: gene ontology, Hetionet, Reactome
6 names
Resolves to: ZNF274