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Proteins/UNIPROT:P40925
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS)..
Function from UniProtKB (P40925), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
356 statements
356 statements · 6 reference databases · Subject: MDH1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
5 reactions
proton+NADH(2-)+oxaloacetate(S)-malate+NAD(+)
Reaction pageReversibleBalancedEC 1.1.1.37cytosol
Human-GEM MAR04139CC BY 4.0Reference data
MAM00179c+NAD(+)MAM00920c+proton+NADH(2-)
Catalysed by MDH1 or
4 names
Resolves to: MDH1
Reaction pageReversibleBalancedEC 1.1.1.37cytosol
Human-GEM MAR08068CC BY 4.0Reference data
(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate+NAD(1-)3-(4-hydroxyphenyl)pyruvate+NADH(2-)+hydron
Catalysed by MDH1
Reaction pageRight to leftBalanced
Rhea RHEA:10780CC BY 4.0Reference data
(S)-malate+NAD(1-)oxaloacetate+NADH(2-)+hydron
Catalysed by PHGDH or MDH1 or MDH2
Reaction pageReversibleBalanced
Rhea RHEA:21432CC BY 4.0Reference data
(S)-2-hydroxyglutarate+NAD(1-)2-oxoglutarate(2-)+NADH(2-)+hydron
Catalysed by MDH1
Reaction pageRight to leftBalanced
Rhea RHEA:57172CC BY 4.0Reference data