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Proteins/UNIPROT:Q15532

SS18

Protein·UNIPROT:Q15532

Open in the graph

Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner..

Function from UniProtKB (Q15532), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

43 statements

43 statements · 3 reference databases · Subject: SS18 · Sources: gene ontology, Hetionet, Reactome

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IGSF8 covaries with SS18ProteinHetionet hetionet:covaries:6760-93185Inferred only
ATF2 interacts with SS18ProteinHetionet hetionet:interacts:1386-6760Inferred only
CNOT2 interacts with SS18ProteinHetionet hetionet:interacts:4848-6760Inferred only
SS18 interacts with CST11ProteinHetionet hetionet:interacts:140880-6760Inferred only
SS18 interacts with CUL3ProteinHetionet hetionet:interacts:6760-8452Inferred only
SS18 interacts with EIF3AProteinHetionet hetionet:interacts:6760-8661Inferred only
EP300 interacts with SS18ProteinHetionet hetionet:interacts:2033-6760Inferred only
GRB2 interacts with SS18ProteinHetionet hetionet:interacts:2885-6760Inferred only
JUN interacts with SS18ProteinHetionet hetionet:interacts:3725-6760Inferred only
SS18 interacts with LRP8ProteinHetionet hetionet:interacts:6760-7804Inferred only
SS18 interacts with NOP58ProteinHetionet hetionet:interacts:51602-6760Inferred only
SS18 interacts with RBM14ProteinHetionet hetionet:interacts:10432-6760Inferred only

Show the remaining 31

SMARCA2 interacts with SS18ProteinHetionet hetionet:interacts:6595-6760Inferred only
SMARCA4 interacts with SS18ProteinHetionet hetionet:interacts:6597-6760Inferred only
SMARCB1 interacts with SS18ProteinHetionet hetionet:interacts:6598-6760Inferred only
SS18 interacts with TTC14ProteinHetionet hetionet:interacts:151613-6760Inferred only
SS18 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
SS18 participates in Affinity selection of immunoglobulinsPathwayReactome R-HSA-9938027Inferred only
SS18 participates in ATP-dependent chromatin remodelersPathwayReactome R-HSA-9932444Inferred only
SS18 participates in Chromatin organizationPathwayReactome R-HSA-4839726Inferred only
SS18 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
SS18 participates in Epigenetic regulation of gene expressionPathwayReactome R-HSA-212165Inferred only
SS18 participates in Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)PathwayReactome R-HSA-9934037Inferred only
SS18 participates in Formation of the canonical BAF (cBAF) complexPathwayReactome R-HSA-9933937Inferred only
SS18 participates in Formation of the embryonic stem cell BAF (esBAF) complexPathwayReactome R-HSA-9933946Inferred only
SS18 participates in Formation of the non-canonical BAF (ncBAF) complexPathwayReactome R-HSA-9933947Inferred only
SS18 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
SS18 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
SS18 participates in Immunoglobulin maturationPathwayReactome R-HSA-9938026Inferred only
SS18 participates in MITF-M-dependent gene expressionPathwayReactome R-HSA-9856651Inferred only
SS18 participates in MITF-M-regulated melanocyte developmentPathwayReactome R-HSA-9730414Inferred only
SS18 participates in Regulation of endogenous retroelementsPathwayReactome R-HSA-9842860Inferred only
SS18 participates in Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)PathwayReactome R-HSA-9845323Inferred only
SS18 participates in Regulation of MITF-M-dependent genes involved in pigmentationPathwayReactome R-HSA-9824585Inferred only
SS18 participates in Somatic hypermutation of immunoglobulin genesPathwayReactome R-HSA-9938024Inferred only
SS18 participates in SWI/SNF chromatin remodelersPathwayReactome R-HSA-9932451Inferred only
SS18 regulates negative regulation of cell differentiationBiological processgene ontology Q15532|GO:0045596Inferred only
SS18 regulates positive regulation of cell population proliferationBiological processgene ontology Q15532|GO:0008284Inferred only
SS18 regulates positive regulation of stem cell population maintenanceBiological processgene ontology Q15532|GO:1902459Inferred only
SS18 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q15532|GO:0045944Inferred only
SS18 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q15532|GO:0006357Inferred only
CAT increases the expression of SS18ProteinHetionet hetionet:regulates:847-6760Inferred only
DYRK3 increases the expression of SS18ProteinHetionet hetionet:regulates:8444-6760Inferred only

Other names

4 names

Resolves to: SS18

Also called: Protein SYTSSXTSynovial sarcoma translocated to X chromosome proteinSYT

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