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Proteins/UNIPROT:O43175
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate..
Function from UniProtKB (O43175), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
475 statements
475 statements · 7 reference databases · Subject: PHGDH · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
5 reactions
2-oxoglutarate(2-)+proton+NADH(2-)MAM00653c+NAD(+)
Catalysed by PHGDH
Reaction pageLeft to rightBalancedEC 1.1.1.95cytosol
Human-GEM MAR00719CC BY 4.0Reference data
(2R)-3-phosphoglycerate+NAD(+)MAM00914c+proton+NADH(2-)
4 names
Resolves to: PHGDH
Human-GEM MAR03839CC BY 4.0Reference data
(2R)-3-phosphoglycerate+NAD(1-)CHEBI:18110+NADH(2-)+hydron
Catalysed by PHGDH
Reaction pageDirection not assertedBalanced
Rhea RHEA:12641CC BY 4.0Reference data
(S)-malate+NAD(1-)oxaloacetate+NADH(2-)+hydron
Catalysed by PHGDH or MDH1 or MDH2
Reaction pageReversibleBalanced
Rhea RHEA:21432CC BY 4.0Reference data
(R)-2-hydroxyglutarate+NAD(1-)2-oxoglutarate(2-)+NADH(2-)+hydron
Catalysed by PHGDH
Reaction pageDirection not assertedBalanced
Rhea RHEA:49612CC BY 4.0Reference data