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Proteins/UNIPROT:P68402
Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity)..
Function from UniProtKB (P68402), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
126 statements
126 statements · 7 reference databases · Subject: PAFAH1B2 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+waterMAM00549c+acetate+proton
Catalysed by PAFAH1B1 or PAFAH1B3 or PAFAH2 or ASPG or PAFAH1B2
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.47cytosol
Human-GEM MAR07611CC BY 4.0Reference data
a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+waterMAM00516c
5 names
Resolves to: PAFAH1B2
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.47cytosol
Human-GEM MAR08518CC BY 4.0Reference data
a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+watera 1-O-alkyl-sn-glycero-3-phosphocholine+acetate+hydron
Catalysed by LCAT or PAFAH1B2 or PLA2G7 or PAFAH1B3 or ASPG or PAFAH2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17777CC BY 4.0Reference data
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine+water1-O-hexadecyl-sn-glycero-3-phosphocholine+acetate+hydron
Catalysed by PLA2G10 or PLA2G6 or PAFAH1B2 or PLA2G7 or PAFAH1B3 or ABHD3 or PAFAH2
Reaction pageLeft to rightBalanced
Rhea RHEA:40479CC BY 4.0Reference data
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate+water1-O-hexadecyl-sn-glycero-3-phosphate+acetate+hydron
Catalysed by PAFAH1B2 or PAFAH1B3
Reaction pageLeft to rightBalanced
Rhea RHEA:41704CC BY 4.0Reference data
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine+water1-O-hexadecyl-sn-glycero-3-phosphoethanolamine+acetate+hydron
Catalysed by PAFAH1B2
Reaction pageLeft to rightBalanced
Rhea RHEA:41708CC BY 4.0Reference data