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Proteins/UNIPROT:Q96GX9
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death..
Function from UniProtKB (Q96GX9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
41 statements
41 statements · 6 reference databases · Subject: APIP · Sources: gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways
2 reactions
MAM02910c5-methylsulfanyl-2,3-dioxopentyl phosphate+water
Catalysed by APIP
Reaction pageLeft to rightBalancedEC 4.2.1.109cytosol
Human-GEM MAR05386CC BY 4.0Reference data
CHEBI:585485-methylsulfanyl-2,3-dioxopentyl phosphate+water
Catalysed by APIP
Reaction pageDirection not assertedBalanced
Rhea RHEA:15549CC BY 4.0Reference data
3 names
Resolves to: APIP