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Proteins/UNIPROT:Q9BX84
Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. Crucial for Mg(2+) homeostasis. Has an important role in epithelial Mg(2+) transport and in the active Mg(2+) absorption in the gut and kidney. However, whether TRPM6 forms functional homomeric channels by itself or functions primarily as a subunit of heteromeric TRPM6-TRPM7 channels, is still under debate..
[TRPM6 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and development..
Function from UniProtKB (Q9BX84), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
20 statements
20 statements · 3 reference databases · Subject: TRPM6 · Sources: Hetionet, Reactome, Rhea
5 reactions
4 names
Resolves to: TRPM6
Rhea RHEA:17989CC BY 4.0Reference data
Transported by TRPA1 or SLC39A6 or SLC39A12 or SLC39A4 or SLC30A10 or SLC39A5 or SLC39A11 or SLC30A7 or TMEM163 or SLC39A7 or SLC39A13 or TRPM7 and 7 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:29351CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data
Transported by TMEM150C or TRPA1 or VDAC1 or GRIA1 or HTR3A or GRIA4 or CLDN10 or NIPAL4 or TMEM63B or NIPAL1 or NIPA1 or PKD1L3 and 17 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29827CC BY 4.0Reference data