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Proteins/UNIPROT:Q7Z3E1
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins. Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR..
Function from UniProtKB (Q7Z3E1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
312 statements
312 statements · 5 reference databases · Subject: TIPARP · Sources: Bgee, gene ontology, Hetionet, Human-GEM, WikiPathways · Rows fetched: 300
4 reactions
6 names
Resolves to: TIPARP
Human-GEM MAR09487CC BY 4.0Reference data
L-aspartyl-[protein]+NAD(1-)4-O-(ADP-D-ribosyl)-L-aspartyl-[protein]+nicotinamide
Catalysed by TNKS or PARP1 or PARP6 or PARP15 or PARP10 or TIPARP or PARP16 or PARP12 or TNKS2 or PARP11 or PARP2 or PARP4 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54424CC BY 4.0Reference data
L-cysteinyl-[protein]+NAD(1-)S-(ADP-D-ribosyl)-L-cysteinyl-[protein]+nicotinamide+hydron
Catalysed by PARP6 or TIPARP or PARP8 or PARP12 or PARP11 or SIRT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56612CC BY 4.0Reference data