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Proteins/UNIPROT:P18847
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter..
[Isoform 2]: Activates transcription presumably by sequestering inhibitory cofactors away from the promoters..
[Isoform 3]: Stress-induced isoform, counteracts the transcriptional repression of isoform 1..
Function from UniProtKB (P18847), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
125 statements
125 statements · 4 reference databases · Subject: ATF3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 names
Resolves to: ATF3