androst-5-ene-3,17-dione

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

59 compounds within 3 steps: 1 in 1, 11 in 2, 47 in 3

One step

androst-4-ene-3,17-dioneReach from here →
1. steroid Delta-isomerase (5-androstene-3,17-dione)
Catalysed by HSD3B1, HSD3B2cytosolOne of 3 routes

Two steps

formateReach from here →
1. steroid Delta-isomerase (5-androstene-3,17-dione)
2. androst-4-ene-3,17-dione + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = estrone + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
Catalysed by HSD3B1, HSD3B2, CYP19A1cytosol
5alpha-androstan-3,17-dioneReach from here →
1. steroid Delta-isomerase (5-androstene-3,17-dione)
2. 5alpha-androstane-3,17-dione:NADP+ delta4-oxidoreductase
Catalysed by HSD3B1, HSD3B2, AKR1D1cytosolOne of 3 routes
5beta-androstane-3,17-dione

Three steps

2-hydroxybutyric acidReach from here →
Catalysed by HSD3B1, HSD3B2, CYP19A1, SLC16A4 and 3 morecytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes
2-hydroxyestroneReach from here →

Reach from here →

Catalysed by HSD3B1, HSD3B2, AKR1D1cytosol

17alpha-hydroxyprogesteroneReach from here →

Catalysed by HSD3B1, HSD3B2, CYP17A1cytosol, endoplasmic reticulum

estroneReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1cytosol, endoplasmic reticulumOne of 2 routes

testosteroneReach from here →

Catalysed by HSD3B1, HSD3B2, HSD17B6, HSD17B1 and 6 morecytosolOne of 4 routes

19-hydroxyandrost-4-ene-3,17-dioneReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1cytosolOne of 2 routes

16alpha-hydroxyandrost-4-ene-3,17-dioneReach from here →

Catalysed by HSD3B1, HSD3B2, CYP17A1cytosol

11beta-hydroxyandrost-4-ene-3,17-dioneReach from here →

Catalysed by HSD3B1, HSD3B2, CYP11B1cytosol

formic acidReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1cytosol, endoplasmic reticulum

6beta-hydroxyandrost-4-ene-3,17-dioneReach from here →

Catalysed by HSD3B1, HSD3B2, CYP3A4, CYP3A5cytosol

Catalysed by HSD3B1, HSD3B2, CYP19A1, CYP3A4cytosol, endoplasmic reticulumOne of 4 routes

estrone 3-O-(beta-D-glucuronate)Reach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, UGT1A1 and 2 morecytosol, endoplasmic reticulumOne of 2 routes

testosterone 17-O-(beta-D-glucuronate)Reach from here →

Catalysed by HSD3B1, HSD3B2, HSD17B6, HSD17B1 and 12 morecytosol, endoplasmic reticulumOne of 2 routes

acetoacetateReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, SLC16A4 and 1 morecytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

1beta-hydroxytestosteroneReach from here →

Catalysed by HSD3B1, HSD3B2, HSD17B6, HSD17B1 and 7 morecytosol

2beta-hydroxytestosteroneReach from here →

Catalysed by HSD3B1, HSD3B2, HSD17B6, HSD17B1 and 7 morecytosol

17beta-hydroxy-androst-5-en-3-oneReach from here →

Catalysed by HSD3B1, HSD3B2, HSD17B6, HSD17B1 and 6 morecytosol

acetaldehydeReach from here →

Catalysed by HSD3B1, HSD3B2, CYP17A1cytosol, endoplasmic reticulum

pyruvateReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, SLC16A4 and 4 morecytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

all-trans-retinoic acidReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, SLC16A4 and 1 morecytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, MTHFD1cytosol, endoplasmic reticulumOne of 2 routes

androsteroneReach from here →

Catalysed by HSD3B1, HSD3B2, AKR1D1, AKR1C4 and 3 morecytosolOne of 6 routes

17beta-hydroxy-5alpha-androstan-3-oneReach from here →

Catalysed by HSD3B1, HSD3B2, HSD17B6, HSD17B1 and 9 morecytosolOne of 4 routes

(17R,20S)-17,20-dihydroxypregn-4-en-3-oneReach from here →

Catalysed by HSD3B1, HSD3B2, CYP17A1, AKR1C1cytosol, endoplasmic reticulumOne of 2 routes

17beta-estradiolReach from here →

Catalysed by HSD3B1, HSD3B2, HSD17B6, HSD17B1 and 7 morecytosol, endoplasmic reticulumOne of 7 routes

formaldehydeReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, ALDH9A1cytosol

(R)-3-hydroxybutyric acidReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, SLC16A4 and 3 morecytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

17alpha-estradiolReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, DHRS1cytosol, endoplasmic reticulum

testosterone 17-sulfateReach from here →

Catalysed by HSD3B1, HSD3B2, HSD17B6, HSD17B1 and 7 morecytosol

(6R)-10-formyltetrahydrofolateReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, MTHFD1 and 1 morecytosol

5beta-dihydrotestosteroneReach from here →

Catalysed by HSD3B1, HSD3B2, HSD17B6, HSD17B1 and 7 morecytosol

androst-4-ene-3,11,17-trioneReach from here →

Catalysed by HSD3B1, HSD3B2, CYP11B1, HSD11B2cytosolOne of 2 routes

11-deoxycortisolReach from here →

Catalysed by HSD3B1, HSD3B2, CYP17A1, CYP21A2cytosol, endoplasmic reticulumOne of 3 routes

chlorine(.)Reach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, SLC26A4cytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

acetateReach from here →

Catalysed by HSD3B1, HSD3B2, CYP17A1cytosol, endoplasmic reticulumOne of 6 routes

oxalateReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, SLC26A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

propionic acidReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, SLC16A4 and 2 morecytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

butyric acidReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, SLC16A4 and 1 morecytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

16alpha,17beta-dihydroxyandrost-4-en-3-oneReach from here →

Catalysed by HSD3B1, HSD3B2, HSD17B6, HSD17B1 and 7 morecytosol

6beta,17beta-dihydroxyandrost-4-en-3-oneReach from here →

Catalysed by HSD3B1, HSD3B2, HSD17B6, HSD17B1 and 7 morecytosol, endoplasmic reticulumOne of 2 routes

(S)-lactic acidReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, SLC16A4 and 5 morecytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, ADI1cytosolOne of 2 routes

3beta-hydroxy-5alpha-androstan-17-oneReach from here →

Catalysed by HSD3B1, HSD3B2, AKR1D1, HSD17B6cytosolOne of 2 routes

S-formylglutathioneReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, ESDcytosol

N-formyl-L-kynurenineReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, AFMIDcytosol

estrone 3-sulfateReach from here →

Catalysed by HSD3B1, HSD3B2, CYP19A1, SULT1A3 and 2 morecytosol, endoplasmic reticulumOne of 3 routes

16alpha,17alpha-dihydroxyprogesteroneReach from here →

Catalysed by HSD3B1, HSD3B2, CYP17A1cytosol, endoplasmic reticulum