Compound
androst-5-ene-3,17-dione
An androstanoid that is androst-5-ene bearing two oxo substituents at positions 3 and 17.
Definition from ChEBI (CHEBI:83865), read 2026-09-23. CC BY 4.0.
Structure
- Class
- Organic compound
- Formula
- C19H26O2
- Mass
- 286.415 g/mol
- Charge
- 0
- InChIKey
- SQGZFRITSMYKRH-QAGGRKNESA-N
- SMILES
- [H][C@@]12CC=C3CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Statements
14 statements
14 statements · 2 reference databases · Subject: androst-5-ene-3,17-dione · Sources: Human-GEM, Rhea
- 3beta-hydroxyandrost-5-en-17-one is converted to androst-5-ene-3,17-dioneCompoundHuman-GEM MAR01968Inferred only
- 3beta-hydroxyandrost-5-en-17-one is converted to androst-5-ene-3,17-dioneCompoundRhea RHEA:43932Inferred only
- 3beta-hydroxyandrost-5-en-17-one is converted to androst-5-ene-3,17-dioneCompoundHuman-GEM MAR01967Inferred only
- androst-5-ene-3,17-dione is converted to androst-4-ene-3,17-dioneCompoundHuman-GEM MAR01970Inferred only
- androst-5-ene-3,17-dione is converted to androst-4-ene-3,17-dioneCompoundHuman-GEM MAR01971Inferred only
- androst-5-ene-3,17-dione is converted to androst-4-ene-3,17-dioneCompoundRhea RHEA:43936Inferred only
- androst-5-ene-3,17-dione is metabolised by GSTA1ProteinRhea RHEA:43936Inferred only
- androst-5-ene-3,17-dione is metabolised by GSTA3ProteinRhea RHEA:43936Inferred only
- androst-5-ene-3,17-dione is a substrate of HSD3B1ProteinHuman-GEM MAR01970Inferred only
- androst-5-ene-3,17-dione is a substrate of HSD3B1ProteinHuman-GEM MAR01971Inferred only
- androst-5-ene-3,17-dione is a substrate of HSD3B1ProteinRhea RHEA:43936Inferred only
- androst-5-ene-3,17-dione is a substrate of HSD3B2ProteinRhea RHEA:43936Inferred only
Show the remaining 2
- androst-5-ene-3,17-dione is a substrate of HSD3B2ProteinHuman-GEM MAR01970Inferred only
- androst-5-ene-3,17-dione is a substrate of HSD3B2ProteinHuman-GEM MAR01971Inferred only
Reactions
6 reactions
3beta-hydroxyandrost-5-en-17-one+NAD(+)androst-5-ene-3,17-dione+proton+NADH(2-)
Reaction pageLeft to rightBalancedEC 1.1.1.145cytosol
Human-GEM MAR01967CC BY 4.0Reference data
3beta-hydroxyandrost-5-en-17-one+NAD(+)androst-5-ene-3,17-dione+proton+NADH(2-)
Reaction pageLeft to rightBalancedEC 1.1.1.145endoplasmic reticulum
Human-GEM MAR01968CC BY 4.0Reference data
androst-5-ene-3,17-dione+proton+NAD(+)androst-4-ene-3,17-dione+NADH(2-)
Reaction pageLeft to rightUnbalancedEC 5.3.3.1cytosol
Human-GEM MAR01970CC BY 4.0Reference data
androst-5-ene-3,17-dione+proton+NAD(+)androst-4-ene-3,17-dione+NADH(2-)
Reaction pageLeft to rightUnbalancedEC 5.3.3.1endoplasmic reticulum
Human-GEM MAR01971CC BY 4.0Reference data
3beta-hydroxyandrost-5-en-17-one+NAD(1-)androst-5-ene-3,17-dione+NADH(2-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:43932CC BY 4.0Reference data
androst-5-ene-3,17-dioneandrost-4-ene-3,17-dione
Catalysed by GSTA1 or HSD3B1 or HSD3B2 or GSTA3
Reaction pageLeft to rightBalanced
Rhea RHEA:43936CC BY 4.0Reference data
Other names
3 names
Resolves to: androst-5-ene-3,17-dione
- Also called
- Delta(5)-androstene-3,17-dionedelta5-Androstene-3,17-dioneΔ5-androstene-3,17-dione