estrone 3-sulfate

Three steps

• 5(S)-HPETEReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by SLCO1B1, ALOX5extracellular space, cytosol

• formateReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by STS, SLC25A14, SLC26A2, SLC25A30 and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• nicotinic acid D-ribonucleotideReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. Transport of Quinolinic Acid
  3. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)

  Catalysed by STS, SLC22A6, QPRTcytosol, extracellular space

• N-carbamoyl-L-aspartic acidReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by STS, SLC25A14, SLC25A30, CADcytosol, inner side of the membrane, outer side of the membrane

• CHEBI:15971Reach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular space

• androsteroneReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. steroid sulfatase (androsterone sulfate)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by STScytosolOne of 3 routes

• octan-1-olReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. octyl beta-D-glucose + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, GBA2extracellular space, cytosol

• ureaReach from here →
  1. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. Peroxidase

  Catalysed by SLC22A24, SLC22A8, SLC22A11, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• L-cystineReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

  Catalysed by STS, SLC25A14, SLC25A30, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by STScytosolOne of 3 routes

• iodideReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC26A4cytosol, extracellular spaceOne of 10 routes

• ubiquinonesReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by STS, SLC25A10, SDHD, SDHB and 2 morecytosol, mitochondrial matrix

• L-valineReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 4 routes

• oxaloacetateReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by STS, SLC25A10cytosol, mitochondrial matrixOne of 11 routes

• L-arginineReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. PROTEIN_BS

  Catalysed by STS, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membrane

• pregnenoloneReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. Steryl-Sulfatase
  3. Pregnenolone-sulfate sulfohydrolase

  Catalysed by STScytosol, Golgi apparatusOne of 4 routes

• (S)-lactateReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. transport of prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 15 routes

• taurochenodeoxycholate 3-sulfateReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)
  3. taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3 and 1 moreextracellular space, cytosol

• dopamine quinoneReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MPOextracellular space, cytosol, lysosomeOne of 4 routes

• 3-fumarylpyruvateReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by STS, SLC25A10, FAHD1cytosol, mitochondrial matrix

• CHEBI:16856Reach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 76 routes

• CHEBI:16857Reach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular space

• ferrocytochrome cReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by STS, SLC25A14, SLC25A30, SUOXcytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrix

• N-acetyl-L-aspartateReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by STS, SLC25A14, SLC25A30, NAT8Lcytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• L-isoleucineReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17203Reach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by STS, SLC26A6, CLTRN, SLC6A20cytosol, extracellular spaceOne of 3 routes

• CHEBI:17208Reach from here →
  1. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. ascorbate to monodehydroascorbate conversion

  Catalysed by SLC22A24, SLC22A8, SLC22A11inner side of the membrane, outer side of the membrane, cytosol

• propanoyl-4'-phosphopantetheineReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate
  3. propanoyl-CoA + H2O = propanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SLC22A9, ACSM3, ACSS3, ACSS2 and 4 moreinner side of the membrane, outer side of the membrane

• dehydroascorbic acidReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DBHextracellular space, cytosol

• enol-oxaloacetateReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by STS, SLC25A10, SDHB, SDHAcytosol, mitochondrial matrix

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA

  Catalysed by SLC22A24, SLC22A8, SLC22A11, CPT2 and 2 moreinner side of the membrane, outer side of the membraneOne of 3 routes

• L-cysteineReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. aryl sulfotransferase (PAPS)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 3 moreextracellular space, cytosolOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 2 moreextracellular space, cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by STScytosol, Golgi apparatusOne of 6 routes

• N-acetylserotoninReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. acetyl-CoA:aralkylamine N-acetyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, AANATextracellular space, cytosol

• xanthineReach from here →
  1. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by SLC22A24, SLC22A8, SLC22A11, XDHinner side of the membrane, outer side of the membraneOne of 2 routes

• glycine betaineReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A12cytosol, extracellular spaceOne of 5 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DDCextracellular space, cytosol

• prostaglandin F1Reach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. prostaglandin E1 + NADPH + H(+) = prostaglandin F1 + NADP(+)

  Catalysed by SLCO1B1, DHRS1extracellular space, cytosol

• 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate)Reach from here →
  1. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC22A24, SLC22A8, SLC22A11, CHST10inner side of the membrane, outer side of the membrane

• estrone 3-O-(3-sulfo-beta-D-glucuronate)Reach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)
  3. estrone 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = estrone 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by STS, UGT1A1, UGT1A10, UGT1A8 and 1 morecytosol, endoplasmic reticulum

• CHEBI:17895Reach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:18019Reach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular space

• thiocyanateReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 3 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by STS, SLC25A10, FAHcytosol, mitochondrial matrix

• L-glutamineReach from here →
  1. Estrone 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 3 routes

• 5-hydroxyisourateReach from here →
  1. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. urate:oxygen oxidoreductase

  Catalysed by SLC22A24, SLC22A8, SLC22A11inner side of the membrane, outer side of the membrane, cytosol

• (R)-3,4-dihydroxymandelaldehydeReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MAOA and 1 moreextracellular space, cytosol