S-sulfanylglutathione

1. Persulfide dioxygenase
2. Glutathione: 5-HPETE oxidoreductase

Catalysed by ETHE1, GPX5, GPX1, GPX2 and 6 moremitochondrial matrix, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and LTD4 (cytosol to extracellular)

Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

Catalysed by ETHE1, CLIC1, GSTO1, GSTO2

1. Persulfide dioxygenase
2. solute carrier organic anion transporter (glycocholate)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 3 routes

1. Persulfide dioxygenase
2. solute carrier organic anion transporter (cholate)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 3 routes

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

Catalysed by ETHE1, TSTD1One of 3 routes

1. Persulfide dioxygenase
2. transport of malonate and sulfite (cytosol to mitochondria)

Catalysed by ETHE1, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

Catalysed by ETHE1, CP, PRDX6

1. Persulfide dioxygenase
2. transport of arachidonate and GSH (cytosol to extracellular)

Catalysed by ETHE1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and serotonin (cytosol to extracellular)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

Catalysed by ETHE1, ABCC4inner side of the membrane, outer side of the membrane

1. Persulfide dioxygenase
2. solute carrier organic anion transporter (GSH)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 3 routes

1. Persulfide dioxygenase
2. transport of glycolithocholate and GSH (cytosol to extracellular)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

Catalysed by ETHE1, CLIC2, GPX1, GPX2 and 2 more

1. Persulfide dioxygenase
2. gamma-glutamyltransferase (alanine)

Catalysed by ETHE1, GGT1, GGT5, GGTLC2 and 3 moremitochondrial matrix, extracellular space, cytosol

1. Persulfide dioxygenase
2. transport of GSH and triiodothyronine (cytosol to extracellular)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and prostaglandin E1 (cytosol to extracellular)

Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and prostaglandin I2 (cytosol to extracellular)

Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and prostaglandin H2 (cytosol to extracellular)

Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and prostaglandin D2 (cytosol to extracellular)

Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. Glutathione: 15-HPETE oxidoreductase

Catalysed by ETHE1, GPX5, GPX1, GPX2 and 6 moremitochondrial matrix, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and leukotriene A4 (cytosol to extracellular)

Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

Catalysed by ETHE1, GLO1, GLOD4mitochondrial matrix, cytosolOne of 3 routes

1. Persulfide dioxygenase
2. alcohol dehydrogenase (formaldehyde)

Catalysed by ETHE1, ADH1C, ADH1A, ADH5 and 3 moremitochondrial matrix, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. leukotriene C4 synthase (GSH)

Catalysed by ETHE1, LTC4Smitochondrial matrix, cytosolOne of 5 routes

1. Persulfide dioxygenase
2. Glutathione: 5-HPETE oxidoreductase

Catalysed by ETHE1, GPX5, GPX1, GPX2 and 6 moremitochondrial matrix, cytosolOne of 36 routes

1. Persulfide dioxygenase
2. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. glutathione = L-cysteinylglycine + 5-oxo-L-proline

Catalysed by ETHE1, CHAC2, CHAC1

1. Persulfide dioxygenase
2. transport of GSH and histamine (cytosol to extracellular)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and thyroxine (cytosol to extracellular)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of dopamine and GSH (cytosol to extracellular)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and prostaglandin E2 (cytosol to extracellular)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. glutathione gamma-glutamylaminopeptidase

Catalysed by ETHE1, GGTLC3, GGT1, GGT5 and 3 moremitochondrial matrix, cytosolOne of 6 routes

1. Persulfide dioxygenase
2. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

Catalysed by ETHE1, SQORmitochondrial matrixOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and noradrenaline (cytosol to extracellular)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

Catalysed by ETHE1, GPX1, GPX4

1. Persulfide dioxygenase
2. transport of GSH and ursodeoxycholate (cytosol to extracellular)

Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Persulfide dioxygenase
2. transport of GSH and prostaglandin G2 (cytosol to extracellular)

Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

Catalysed by ETHE1, ABCC4inner side of the membrane, outer side of the membrane

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

Catalysed by ETHE1, GPX1, GPX2, GPX4

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

Catalysed by ETHE1, PTGES, MGST3, GPX1 and 3 more

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

Catalysed by ETHE1, GPX1, GPX4

1. Persulfide dioxygenase
2. transport of GSH and thromboxane B2 (cytosol to extracellular)

Catalysed by ETHE1, SLCO1B1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

Catalysed by ETHE1, GSTT4, GSTA4, GSTZ1 and 20 moreOne of 2 routes

1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
2. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

Catalysed by ETHE1, GPX1, GSTA1, GPX2 and 1 more

1. Persulfide dioxygenase
2. solute carrier organic anion transporter (GSH)

Catalysed by ETHE1, SLCO1A2, SLC7A9, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 3 routes

1. Persulfide dioxygenase
2. transport of arachidonate and GSH (cytosol to extracellular)
3. Utilized Transport

Catalysed by ETHE1mitochondrial matrix, extracellular space, cytosol, endoplasmic reticulumOne of 2 routes