a 1,2-diacyl-sn-glycero-3-phosphocholine

Three steps

• CHEBI:15650Reach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by LPGAT1, GPAT3, GPAT2, GPAT4 and 33 moremitochondrial matrix, cytosolOne of 2 routes

• all-trans-3-hydroxyretinolReach from here →
  1. all-trans-retinol--[retinol-binding protein] + a 1,2-diacyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholine
  2. carboxylesterase (retinyl-ester)
  3. all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O

  Catalysed by LRAT, CES2, RBP4, LIPF and 18 morecytosol

• CHEBI:15727Reach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by LPGAT1, GPAT3, GPAT2, GPAT4 and 2 moremitochondrial matrix, cytosol

• CHEBI:15746Reach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by LPGAT1, GPAT3, GPAT2, GPAT4 and 3 moremitochondrial matrix, cytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Palmitoyl-CoA hydrolase

  Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 14 routes

• 1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. plasmenylethanolamine 2-acylhydrolase

  Catalysed by LPGAT1, LPCAT4, LPCAT3, LPCAT2 and 19 morecytosol

• a 1-O-alkyl-sn-glycerolReach from here →
  1. a 2-acylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
  2. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol
  3. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycerol + phosphocholine + H(+)

  Catalysed by PLA2G15, TMEM68, ENPP6

• CHEBI:15971Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by PLD2, PLD1, ENPP2, SLC5A7 and 1 moreextracellular space, cytosol

• CHEBI:15978Reach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. 2 a 2-acyl-sn-glycero-3-phosphocholine = sn-glycerol 3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphocholine
  3. sn-Glycero-3-phosphocholine glycerophosphohydrolase

  Catalysed by LPGAT1, ASPG, GPCPD1cytosol

• 11-cis-retinalReach from here →
  1. all-trans-retinol--[retinol-binding protein] + a 1,2-diacyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholine
  2. all-trans-retinyl ester acylhydrolase, 11-cis-retinol forming
  3. 11-cis-retinol:NAD+ oxidoreductase

  Catalysed by LRAT, RPE65, HSD17B6, RDH16 and 5 morecytosolOne of 4 routes

• hexadecan-1-olReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by LPGAT1, FAR1, FAR2cytosol, peroxisome

• sulfateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by PLD2, PLD1, ENPP2, SLC5A7 and 1 moreextracellular space, cytosol

• 11-cis-retinyl hexadecanoateReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by LPGAT1, DGAT1, LRAT, AWAT1 and 2 morecytosolOne of 3 routes

• cob(II)alaminReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by PLD2, PLD1, ENPP2, CHDH and 1 more

• iodideReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by PLD2, PLD1, ENPP2, SLC5A7 and 1 moreextracellular space, cytosolOne of 23 routes

• L-valineReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by PLD2, PLD1, ENPP2, SLC5A7 and 1 moreextracellular space, cytosolOne of 2 routes

• oxaloacetateReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by LPGAT1, GPAT3, GPAT2, GPAT4 and 2 moremitochondrial matrix, cytosol

• L-arginineReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by PLD2, PLD1, ENPP2, SLC5A7 and 1 moreextracellular space, cytosolOne of 2 routes

• nitric oxideReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O

  Catalysed by PLD2, PLD1, ENPP2, CHDH and 1 more

• CHEBI:16566Reach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. sphingosine N-acyltransferase (sphinganine)
  3. N-acylsphingosine amidohydrolase

  Catalysed by LPGAT1, CERS1, CERS6, CERS3 and 8 morecytosol

• pregnenoloneReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O

  Catalysed by OSBPL3, OSBP, CYP11A1inner side of the membrane, outer side of the membrane

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by PLD2, PLD1, ENPP2, CHDH and 1 more

• (S)-2-hydroxyglutarateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by PLD2, PLD1, ENPP2, CHDH and 1 more

• CHEBI:16856Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by PLD2, PLD1, ENPP2, CHAT and 2 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:16857Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by PLD2, PLD1, ENPP2, SLC5A7 and 1 moreextracellular space, cytosol

• oxalic acidReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by PLD2, PLD1, ENPP2, SLC5A7 and 1 moreextracellular space, cytosol

• L-isoleucineReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by PLD2, PLD1, ENPP2, SLC5A7 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:17203Reach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by PLD2, PLD1, ENPP2, SLC5A7 and 2 moreextracellular space, cytosolOne of 2 routes

• S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheineReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by LPGAT1, NUDT19cytosol

• S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by LPGAT1, NUDT19cytosol

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by LPGAT1, NUDT19cytosol

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by LPGAT1, CERS1cytosol

• myo-inositolReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
  3. a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)

  Catalysed by LPGAT1, LCLAT1, MBOAT7, CDIPTOne of 4 routes

• anilineReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by LPGAT1, GPAT3, GPAT2, GPAT4 and 3 moremitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by LPGAT1, GPAT3, GPAT2, GPAT4 and 1 moremitochondrial matrix, cytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by PLD2, PLD1, ENPP2, CHDH and 1 moreOne of 4 routes

• linoleic acidReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. Linoleoyl-CoA hydrolase

  Catalysed by LPGAT1, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 13 routes

• D-glyceraldehydeReach from here →
  1. a 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,3-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
  2. a 1-acylglycerol + a 1,3-diacylglycerol = a triacylglycerol + glycerol
  3. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)

  Catalysed by PLA2G15, PNPLA4, PNPLA2, PNPLA3 and 2 more

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA pool formation and breakdown
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by LPGAT1, CPT2, CPT1Acytosol, peroxisomeOne of 4 routes

• cholesteryl 3-beta-D-glucosideReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine

  Catalysed by OSBPL3, OSBP, GBA1, GBA2inner side of the membrane, outer side of the membraneOne of 7 routes

• 7alpha-hydroxycholesterolReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by OSBPL3, OSBP, CYP7A1inner side of the membrane, outer side of the membrane

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. phosphatidylcholine 2-acylhydrolase

  Catalysed by LPGAT1, LPCAT4, LPCAT3, LPCAT2 and 19 morecytosol, endoplasmic reticulumOne of 10 routes

• L-cysteineReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by LPGAT1, GPAT3, GPAT2, GPAT4 and 2 moremitochondrial matrixOne of 3 routes

• all-trans-retinyl hexadecanoateReach from here →
  1. all-trans-retinol--[retinol-binding protein] + a 1,2-diacyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholine
  2. carboxylesterase (retinyl-ester)
  3. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA

  Catalysed by LRAT, CES2, RBP4, LIPF and 21 morecytosolOne of 5 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by PLD2, PLD1, ENPP2, CHDH and 1 more

• 3,3'-diiodo-L-thyronineReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

  Catalysed by PLD2, PLD1, ENPP2, CHDH and 2 moreOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2

  Catalysed by PLD2, PLD1, ENPP2, CHDH and 1 moreOne of 2 routes

• 26-hydroxycholesterolReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 26-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by OSBPL3, OSBP, CYP3A4inner side of the membrane, outer side of the membrane

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by LPGAT1, GPAT3, GPAT2, GPAT4 and 4 moremitochondrial matrixOne of 2 routes

• glycine betaineReach from here →
  1. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline dehydrogenase (choline)
  3. p-cumic alcohol:NAD+ oxidoreductase

  Catalysed by PLD2, PLD1, ENPP2, CHDH and 1 morecytosolOne of 7 routes