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Reference

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7alpha-hydroxycholesterol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

4 compounds within 3 steps: 2 in 1, 1 in 2, 1 in 3

Does it reach a compound?

One step

7alpha-hydroxycholest-4-en-3-oneReach from here →
1. 7alpha-Hydroxycholesterol:NAD+ 3-oxidoreductase
Catalysed by HSD3B7endoplasmic reticulumOne of 4 routes
(24S)-7alpha-dihydroxycholesterolReach from here →
1. 7alpha-hydroxycholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-7alpha-dihydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CYP46A1

Two steps

25-hydroxycholesterolReach from here →
1. 7alpha-Hydroxycholesterol:NAD+ 3-oxidoreductase
2. Cholest-5-Ene-3Beta, 7Alpha-Diol:NAD+ 3-Oxidoreductase Bile Acid Biosynthesis
Catalysed by HSD3B7endoplasmic reticulum

Three steps

7alpha,25-dihydroxycholesterolReach from here →
Catalysed by HSD3B7, CYP7B1endoplasmic reticulumOne of 2 routes