Compound
26-hydroxycholesterol
An oxysterol that is cholesterol substituted at position 26 by a hydroxy group.
Definition from ChEBI (CHEBI:17703), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C27H46O2
- Mass
- 402.663 g/mol
- Charge
- 0
- InChIKey
- FYHRJWMENCALJY-CCDZVGGQSA-N
- SMILES
- [H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1([H])[C@H](C)CCCC(C)CO
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
1 entity
1 entities reached.
0 reported hops1 assembled from the scaffold
What the reference databases state
Chemical structure
- 26-hydroxycholesterol has the functional parent cholesterolCompoundChEBI CHEBI:17703Inferred only
Statements
1 statement
1 statement · 1 reference database · Subject: 26-hydroxycholesterol · Sources: Rhea
- 26-hydroxycholesterol is metabolised by CYP3A4ProteinRhea RHEA:50264Inferred only
Reactions
3 reactions
cholesterol+NADPH(4-)+dioxygen+hydron26-hydroxycholesterol+NADP(3-)+water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:43836CC BY 4.0Reference data
26-hydroxycholesterol+2reduced [2Fe-2S]-[ferredoxin]+dioxygen+2hydronCHEBI:84145+2oxidized [2Fe-2S]-[ferredoxin]+2water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:43840CC BY 4.0Reference data
cholesterol+reduced [NADPH--hemoprotein reductase]+dioxygen26-hydroxycholesterol+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP3A4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:50264CC BY 4.0Reference data
Other names
8 names
Resolves to: 26-hydroxycholesterol
- Also called
- 26-hydroxy-cholesterol27-hydroxy-cholesterol27-Hydroxycholesterolcholest-5-en-3beta,26-diolCholest-5-ene-3beta,26-diolCholest-5-ene-3beta,27-diolST 27:1;O2
- Systematic name
- cholest-5-ene-3β,26-diol