(R)-S-lactoylglutathione

Three steps

• 2-iminopropanoateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by HAGH, HAGHL, LDHD, RIDAcytosol, mitochondrial matrix

• phosphoenolpyruvic acidReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. pyruvate kinase (dTDP)

  Catalysed by HAGH, HAGHL, LDHD, PKM and 1 morecytosol, mitochondrial matrix

• N-acetyl-beta-neuraminic acidReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by HAGH, HAGHL, LDHD, NPLcytosol, mitochondrial matrix

• L-ornithineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A6cytosol, extracellular spaceOne of 2 routes

• N-methylserotoninReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:amine N-methyltransferase

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular space

• Cu(+)Reach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
  3. Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

  Catalysed by HAGH, CLIC1, GSTO1, GSTO2 and 1 moreinner side of the membrane, outer side of the membrane

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. 5-Hydroxytryptamine:oxygen oxidoreductase(deaminating)(flavin-containing)

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 2 morecytosol, extracellular spaceOne of 2 routes

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by HAGH, HAGHL, FAAHcytosol, extracellular space

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by HAGH, SQOR, NQO2

• malonaldehydeReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)
  3. thromboxane A synthase (12(S)-HHT)

  Catalysed by HAGH, HAGHL, SLCO2A1, TBXAS1cytosol, extracellular spaceOne of 2 routes

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 2 morecytosol, extracellular space

• a 3-acylpyruvateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by HAGH, HAGHL, LDHD, FAHD1cytosol, mitochondrial matrix

• glycineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. leukotriene C4 synthase (GSH)
  3. leukotriene C4 hydrolysis

  Catalysed by HAGH, HAGHL, LTC4ScytosolOne of 12 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by HAGH, HAGHL, SLC27A2, ACSL4 and 9 morecytosol, extracellular space

• choloyl-CoAReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. solute carrier organic anion transporter (cholate)
  3. cholate + ATP + CoA = choloyl-CoA + AMP + diphosphate

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular space

• 15-oxoprostaglandin E2Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular spaceOne of 2 routes

• 15-oxoprostaglandin E1Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  3. (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase

  Catalysed by HAGH, HAGHL, SLCO2A1, CBR3 and 2 morecytosol, extracellular spaceOne of 3 routes

• 15-oxoprostaglandin D2Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. 15-dehydro-prostaglandin D2 reduction

  Catalysed by HAGH, HAGHL, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. Glutathione: 15-HPETE oxidoreductase
  3. (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NADP+ 15-oxidoreductase

  Catalysed by HAGH, HAGHL, GPX5, GPX1 and 7 morecytosolOne of 3 routes

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by HAGH, HAGHL, ALOX5, ALOX15 and 1 morecytosol, extracellular space

• thromboxane A2Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. thromboxane A2 hydrolysis

  Catalysed by HAGH, HAGHL, SLCO1B1cytosol, extracellular space, endoplasmic reticulumOne of 4 routes

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by HAGH, HAGHL, ALOX15B, ALOX15 and 1 morecytosol, extracellular space

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by HAGH, HAGHL, ALOX5cytosol, extracellular space

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by HAGH, HAGHL, LDHDcytosol, mitochondrial matrix

• L-dopaReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. L-dopa + H(+) = dopamine + CO2

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular space

• L-histidineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and histamine (cytosol to extracellular)
  3. L-histidine + H(+) = histamine + CO2

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular space

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by HAGH, HAGHL, LDHD, MPSTcytosol, mitochondrial matrixOne of 5 routes

• 2-methyl-3-oxopropanoateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by HAGH, HAGHL, LDHD, AGXT2cytosol, mitochondrial matrix

• L-methionineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by HAGH, HAGHL, LDHD, TYW1B and 1 morecytosol, mitochondrial matrixOne of 9 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by HAGH, PTGES, LANCL1, GSTM4 and 2 moreextracellular space, cytosolOne of 2 routes

• L-tryptophanReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of cysteine and tryptophan (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A5cytosol, extracellular spaceOne of 4 routes

• L-alanineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by HAGH, HAGHL, LDHD, AGXT2cytosol, mitochondrial matrixOne of 34 routes

• L-asparagineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A5cytosol, extracellular spaceOne of 4 routes

• L-phenylalanineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A5cytosol, extracellular spaceOne of 6 routes

• L,L-cystathionineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. Formation of Homocystine
  3. L-serine hydro-lyase (adding homocysteine

  Catalysed by HAGH, HAGHL, CBScytosol

• gamma-L-glutamyl-L-cysteineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by HAGH, HAGHL, GCLC, GCLMcytosolOne of 2 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by HAGH, SQOR, PRODH2

• S-sulfanyl-L-cysteineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by HAGH, HAGHL, CARS2cytosol

• N(tau)-methylhistamineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and histamine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:histamine N-tele-methyltransferase

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular spaceOne of 3 routes

• (3S)-citramalyl-CoAReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by HAGH, HAGHL, LDHD, CLYBLcytosol, mitochondrial matrix

• 5-amino-2-oxopentanoateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by HAGH, HAGHL, LDHD, AGXT2cytosol, mitochondrial matrix

• hyodeoxycholateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and lithocholate (cytosol to extracellular)
  3. cytochrome P450 (lithocholate)

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular space

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine

  Catalysed by HAGH, HAGHL, FAAH, PM20D1cytosol, extracellular space

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by HAGH, HAGHL, PPCScytosolOne of 4 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular spaceOne of 20 routes

• L-prolineReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by HAGH, SQOR, PRODH, PRODH2

• estrone 3-sulfateReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by HAGH, PTGES, LANCL1, GSTM4 and 2 moreextracellular space, cytosolOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by HAGH, HAGHL, CDO1cytosolOne of 2 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by HAGH, HAGHL, LDHD, HOGA1cytosol, mitochondrial matrix

• leukotriene D4Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. leukotriene C4 synthase (GSH)
  3. leukotriene C4 + H2O = leukotriene D4 + L-glutamate

  Catalysed by HAGH, HAGHL, LTC4S, GGT1 and 1 morecytosol